Syk protein · SINGLE PROTEIN · Mus musculus
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As of 2026-09-15Protein identity stays anchored to UniProt P48025. Use UniProt P48025 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P48025 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein kinase SYK
Review this target as Syk protein, mapped to UniProt P48025. ChEMBL maps the protein component as Tyrosine-protein kinase SYK. Sequence length is 629 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Syk protein as ChEMBL target CHEMBL1932898, mapped to UniProt P48025. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Syk protein is the right protein anchor across sources, using UniProt P48025 as the stable mapping.
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| Preferred Name | Syk protein |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P48025 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase SYK |
| UniProt Accession | P48025 |
| Component Type | Protein |
| Sequence Length | 629 aa |
Tyrosine-protein kinase SYK
Review this target as Syk protein, mapped to UniProt P48025. ChEMBL maps the protein component as Tyrosine-protein kinase SYK. Sequence length is 629 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5556121 | 8.87 | IC50 | 1.346 | Preclinical |
| CHEMBL5559304 | 7.57 | IC50 | 27.0 | Preclinical |
| CHEMBL5560300 | 7.41 | IC50 | 39.0 | Preclinical |
| CHEMBL5560246 | 7.23 | IC50 | 59.0 | Preclinical |
| CHEMBL5555133 | 7.16 | IC50 | 69.0 | Preclinical |
| CHEMBL5542369 | 7.05 | IC50 | 90.0 | Preclinical |
| CHEMBL5555997 | 7.01 | IC50 | 98.0 | Preclinical |
| CHEMBL5558131 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL5567912 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL5542681 | 6.85 | IC50 | 142.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 13 | 6.5 |
| single protein format | 2 | 19 | 5.8 |