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Target Snapshot

CHEMBL1932910 Target Snapshot

ATP-dependent Clp protease proteolytic subunit · SINGLE PROTEIN · Staphylococcus aureus (strain NCTC 8325)

131Compounds
36Assays
0Approved Drugs
151.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q2G036. Use UniProt Q2G036 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q2G036 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats ATP-dependent Clp protease proteolytic subunit as ChEMBL target CHEMBL1932910, mapped to UniProt Q2G036. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
ATP-dependent Clp protease proteolytic subunit
SINGLE PROTEIN · Staphylococcus aureus (strain NCTC 8325)
As of 2026-09-14
ChEMBL target ID
CHEMBL1932910
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q2G036
ATP-dependent Clp protease proteolytic subunit
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether ATP-dependent Clp protease proteolytic subunit is the right protein anchor across sources, using UniProt Q2G036 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelATP-dependent Clp protease proteolytic subunit
UniProt AccessionQ2G036
Component TypeProtein
Sequence Length195 aa

ATP-dependent Clp protease proteolytic subunit

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as ATP-dependent Clp protease proteolytic subunit, mapped to UniProt Q2G036. Sequence length is 195 aa.

Mapped IDQ2G036
Review nameATP-dependent Clp protease proteolytic subunit
OrganismStaphylococcus aureus (strain NCTC 8325)
Clinical Profile

Clinical Phase Distribution

4
Phase III
Assay Mix

Activity Type Distribution

IC5061.0
EC5089.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4579446 6.72 EC50 190.0 Preclinical
CHEMBL4536651 6.6 EC50 250.0 Preclinical
CHEMBL4582486 6.6 EC50 250.0 Preclinical
CHEMBL4593456 6.55 EC50 280.0 Preclinical
CHEMBL4542946 6.54 EC50 290.0 Preclinical
CHEMBL4530326 6.51 EC50 310.0 Preclinical
CHEMBL4549148 6.51 EC50 310.0 Preclinical
CHEMBL4551784 6.51 EC50 310.0 Preclinical
CHEMBL3764224 6.5 EC50 320.0 Preclinical
CHEMBL4537982 6.5 EC50 320.0 Preclinical
Distribution

pChEMBL Value Distribution

63
5.0
29
5.5
31
6.0
12
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

36
Total Assays
116
Tested Compounds
1
Assay Types
Binding — 36 assays, 116 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 21 65 5.3
single protein format 15 51 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine