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Target Snapshot

CHEMBL1935 Target Snapshot

Aldehyde dehydrogenase, mitochondrial · SINGLE PROTEIN · Homo sapiens

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374Compounds
71Assays
1Approved Drugs
299.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Aldehyde dehydrogenase, mitochondrial shows approved-linked disease relevance led by alcohol dependence. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P05091. Start with alcohol dependence, then reuse UniProt P05091 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with alcohol dependence, then reuse UniProt P05091 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
alcohol dependence

Aldehyde dehydrogenase, mitochondrial shows approved-linked disease relevance led by alcohol dependence. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with alcohol dependence because it currently carries approved-linked support. Linked drugs include DISULFIRAM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Aldehyde dehydrogenase, mitochondrial as ChEMBL target CHEMBL1935, mapped to UniProt P05091. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Aldehyde dehydrogenase, mitochondrial
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1935
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P05091
Aldehyde dehydrogenase, mitochondrial
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Aldehyde dehydrogenase, mitochondrial is the right protein anchor across sources, using UniProt P05091 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why alcohol dependence is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameAldehyde dehydrogenase, mitochondrial
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP05091
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAldehyde dehydrogenase, mitochondrial
UniProt AccessionP05091
Component TypeProtein
Sequence Length517 aa

Aldehyde dehydrogenase, mitochondrial

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Aldehyde dehydrogenase, mitochondrial, mapped to UniProt P05091. Sequence length is 517 aa.

Mapped IDP05091
Review nameAldehyde dehydrogenase, mitochondrial
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Aldehyde dehydrogenase, mitochondrial shows approved-linked disease relevance led by alcohol dependence. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
alcohol dependence
1 linked drug · 1 direct · 1 efficacy
Linked drugDISULFIRAM
Approved-linked Approved
parasitic infection
1 linked drug · 1 direct · 1 efficacy
Linked drugDISULFIRAM
Clinical signal Phase II
alcohol-related disorders
1 linked drug · 1 direct · 1 efficacy
Linked drugDISULFIRAM
Clinical signal Phase II
breast cancer
1 linked drug · 1 direct · 1 efficacy
Linked drugDISULFIRAM
Clinical signal Phase II
breast neoplasm
1 linked drug · 1 direct · 1 efficacy
Linked drugDISULFIRAM
Clinical signal Phase II
cocaine abuse
1 linked drug · 1 direct · 1 efficacy
Linked drugDISULFIRAM
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with alcohol dependence because it currently carries approved-linked support. Linked drugs include DISULFIRAM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasealcohol dependence
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC50283.0
KI13.0
EC503.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3660752 8.64 IC50 2.3 Preclinical
CHEMBL113123 8.52 IC50 3.0 Preclinical
CHEMBL112696 8.4 IC50 4.0 Preclinical
CHEMBL3660748 8.4 IC50 4.0 Preclinical
CHEMBL3660728 8.3 IC50 5.0 Preclinical
CHEMBL3660742 8.3 IC50 5.0 Preclinical
CHEMBL3660747 8.3 IC50 5.0 Preclinical
CHEMBL3660751 8.3 IC50 5.0 Preclinical
CHEMBL3660744 8.22 IC50 6.0 Preclinical
CHEMBL3660739 8.22 IC50 6.0 Preclinical
Distribution

pChEMBL Value Distribution

20
5.0
44
5.5
29
6.0
41
6.5
34
7.0
12
7.5
17
8.0
2
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

71
Total Assays
177
Tested Compounds
2
Assay Types
Binding — 66 assays, 177 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 46 123 6.5
cell-based format 10 0 —
assay format 9 54 6.4
tissue-based format 1 0 —
Functional — 5 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
mitochondrion format 4 0 —
assay format 1 1 7.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine