Mast/stem cell growth factor receptor Kit · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Mast/stem cell growth factor receptor Kit shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 25 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P10721. Start with neoplasm, then reuse UniProt P10721 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P10721 as the stable protein anchor across project notes and exports.
Mast/stem cell growth factor receptor Kit shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 25 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AMUVATINIB, AVAPRITINIB, CATEQUENTINIB, CEDIRANIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMast/stem cell growth factor receptor Kit
Review this target as Mast/stem cell growth factor receptor Kit, mapped to UniProt P10721. Sequence length is 976 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mast/stem cell growth factor receptor Kit as ChEMBL target CHEMBL1936, mapped to UniProt P10721. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Mast/stem cell growth factor receptor Kit is the right protein anchor across sources, using UniProt P10721 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 25 linked drugs in the same disease frame.
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| Preferred Name | Mast/stem cell growth factor receptor Kit |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P10721 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mast/stem cell growth factor receptor Kit |
| UniProt Accession | P10721 |
| Component Type | Protein |
| Sequence Length | 976 aa |
Mast/stem cell growth factor receptor Kit
Review this target as Mast/stem cell growth factor receptor Kit, mapped to UniProt P10721. Sequence length is 976 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Mast/stem cell growth factor receptor Kit shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AMUVATINIB, AVAPRITINIB, CATEQUENTINIB, CEDIRANIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4448433 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL404366 | 9.8 | Ki | 0.1585 | Preclinical |
| CHEMBL3683258 | 9.74 | IC50 | 0.18 | Preclinical |
| CHEMBL273187 | 9.7 | Ki | 0.1995 | Preclinical |
| CHEMBL535 | 9.68 | Kd | 0.21 | Approved |
| CHEMBL4204794 | 9.62 | IC50 | 0.24 | Approved |
| CHEMBL1721885 | 9.6 | Kd | 0.25 | Clinical |
| CHEMBL373798 | 9.6 | Ki | 0.2512 | Preclinical |
| CHEMBL491473 | 9.57 | Kd | 0.27 | Clinical |
| CHEMBL402846 | 9.5 | Ki | 0.3162 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1,392 | 1,543 | 7.0 |
| cell-based format | 435 | 1,408 | 6.1 |
| assay format | 368 | 587 | 6.8 |
| organism-based format | 6 | 496 | 7.2 |
| subcellular format | 1 | 1 | 7.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 15 | 18 | 6.0 |
| single protein format | 13 | 33 | 6.5 |
| assay format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 19 | 24 | 6.8 |
| assay format | 3 | 143 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 18 | 5.6 |