Lysine-specific histone demethylase 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q8NB78. Use UniProt Q8NB78 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8NB78 as the stable identity anchor, then attach disease evidence before program review.
Lysine-specific histone demethylase 2
Review this target as Lysine-specific histone demethylase 2, mapped to UniProt Q8NB78. Sequence length is 822 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lysine-specific histone demethylase 2 as ChEMBL target CHEMBL1938208, mapped to UniProt Q8NB78. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Lysine-specific histone demethylase 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8NB78 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lysine-specific histone demethylase 2 |
| UniProt Accession | Q8NB78 |
| Component Type | Protein |
| Sequence Length | 822 aa |
Lysine-specific histone demethylase 2
Review this target as Lysine-specific histone demethylase 2, mapped to UniProt Q8NB78. Sequence length is 822 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1232461 | 6.92 | IC50 | 120.0 | Clinical |
| CHEMBL5206450 | 6.22 | IC50 | 600.0 | Preclinical |
| CHEMBL5191047 | 6.12 | IC50 | 760.0 | Preclinical |
| CHEMBL5205837 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL5181753 | 6.0 | IC50 | 1010.0 | Preclinical |
| CHEMBL5196564 | 5.99 | IC50 | 1020.0 | Preclinical |
| CHEMBL4170687 | 5.84 | IC50 | 1430.0 | Preclinical |
| CHEMBL5177857 | 5.83 | IC50 | 1480.0 | Preclinical |
| CHEMBL4857247 | 5.8 | IC50 | 1600.0 | Preclinical |
| CHEMBL5194745 | 5.65 | IC50 | 2260.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 25 | 53 | 5.1 |
| cell-based format | 6 | 34 | 4.5 |
| assay format | 1 | 3 | 4.4 |