Lysine-specific demethylase 2A · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9Y2K7. Use UniProt Q9Y2K7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y2K7 as the stable identity anchor, then attach disease evidence before program review.
Lysine-specific demethylase 2A
Review this target as Lysine-specific demethylase 2A, mapped to UniProt Q9Y2K7. Sequence length is 1162 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lysine-specific demethylase 2A as ChEMBL target CHEMBL1938210, mapped to UniProt Q9Y2K7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Lysine-specific demethylase 2A |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y2K7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lysine-specific demethylase 2A |
| UniProt Accession | Q9Y2K7 |
| Component Type | Protein |
| Sequence Length | 1162 aa |
Lysine-specific demethylase 2A
Review this target as Lysine-specific demethylase 2A, mapped to UniProt Q9Y2K7. Sequence length is 1162 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2392184 | 8.09 | Kd | 8.2 | Preclinical |
| CHEMBL2392184 | 7.95 | Ki | 11.3 | Preclinical |
| CHEMBL3621881 | 7.2 | IC50 | 63.1 | Preclinical |
| CHEMBL5173876 | 7.2 | IC50 | 63.0 | Preclinical |
| CHEMBL4283409 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL4288093 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL4294926 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL3621878 | 6.9 | IC50 | 125.89 | Preclinical |
| CHEMBL2392184 | 6.87 | IC50 | 135.0 | Preclinical |
| CHEMBL5723343 | 6.8 | IC50 | 160.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 19 | 16 | 5.8 |
| single protein format | 17 | 75 | 5.3 |
| cell-based format | 11 | 29 | 5.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 6.8 |