1-phosphatidylinositol 3-phosphate 5-kinase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-141-phosphatidylinositol 3-phosphate 5-kinase shows clinical signal disease relevance led by Crohn's disease. 3 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q9Y2I7. Start with Crohn's disease, then reuse UniProt Q9Y2I7 as the stable protein anchor across project notes and exports.
Start with Crohn's disease, then reuse UniProt Q9Y2I7 as the stable protein anchor across project notes and exports.
1-phosphatidylinositol 3-phosphate 5-kinase shows clinical signal disease relevance led by Crohn's disease. 3 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with Crohn's disease because it currently carries clinical signal support. Linked drugs include APILIMOD, APILIMOD MESYLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxy1-phosphatidylinositol 3-phosphate 5-kinase
Review this target as 1-phosphatidylinositol 3-phosphate 5-kinase, mapped to UniProt Q9Y2I7. Sequence length is 2098 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 1-phosphatidylinositol 3-phosphate 5-kinase as ChEMBL target CHEMBL1938222, mapped to UniProt Q9Y2I7. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether 1-phosphatidylinositol 3-phosphate 5-kinase is the right protein anchor across sources, using UniProt Q9Y2I7 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Crohn's disease is currently framed as clinical signal support. It currently carries 2 linked drugs in the same disease frame.
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| Preferred Name | 1-phosphatidylinositol 3-phosphate 5-kinase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y2I7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 1-phosphatidylinositol 3-phosphate 5-kinase |
| UniProt Accession | Q9Y2I7 |
| Component Type | Protein |
| Sequence Length | 2098 aa |
1-phosphatidylinositol 3-phosphate 5-kinase
Review this target as 1-phosphatidylinositol 3-phosphate 5-kinase, mapped to UniProt Q9Y2I7. Sequence length is 2098 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
1-phosphatidylinositol 3-phosphate 5-kinase shows clinical signal disease relevance led by Crohn's disease. 3 more disease programs remain visible in the same review block.
Start review with Crohn's disease because it currently carries clinical signal support. Linked drugs include APILIMOD, APILIMOD MESYLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4297643 | 10.12 | Kd | 0.075 | Clinical |
| CHEMBL4297643 | 9.51 | IC50 | 0.309 | Clinical |
| CHEMBL5572490 | 9.33 | Kd | 0.47 | Preclinical |
| CHEMBL2178735 | 9.09 | IC50 | 0.82 | Preclinical |
| CHEMBL5555919 | 9.04 | Kd | 0.91 | Preclinical |
| CHEMBL4303292 | 8.92 | IC50 | 1.19 | Preclinical |
| CHEMBL5568998 | 8.78 | Kd | 1.65 | Preclinical |
| CHEMBL5189479 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL5557909 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL5193848 | 8.72 | IC50 | 1.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 38 | 37 | 7.0 |
| cell-based format | 26 | 49 | 7.3 |
| assay format | 20 | 5 | 7.3 |
| subcellular format | 12 | 1 | 7.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |