Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL1944498 Target Snapshot

Carbonic anhydrase 3 · SINGLE PROTEIN · Bos taurus

27Compounds
1Assays
3Approved Drugs
27.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q3SZX4. Use UniProt Q3SZX4 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q3SZX4 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Carbonic anhydrase 3 as ChEMBL target CHEMBL1944498, mapped to UniProt Q3SZX4. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Carbonic anhydrase 3
SINGLE PROTEIN · Bos taurus
As of 2026-09-14
ChEMBL target ID
CHEMBL1944498
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q3SZX4
Carbonic anhydrase 3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Carbonic anhydrase 3 is the right protein anchor across sources, using UniProt Q3SZX4 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCarbonic anhydrase 3
UniProt AccessionQ3SZX4
Component TypeProtein
Sequence Length260 aa

Carbonic anhydrase 3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Carbonic anhydrase 3, mapped to UniProt Q3SZX4. Sequence length is 260 aa.

Mapped IDQ3SZX4
Review nameCarbonic anhydrase 3
OrganismBos taurus
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

KI27.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL596277 5.67 Ki 2130.0 Preclinical
CHEMBL280998 5.46 Ki 3480.0 Preclinical
CHEMBL1668603 5.37 Ki 4240.0 Preclinical
CHEMBL593507 5.36 Ki 4340.0 Preclinical
CHEMBL607823 5.33 Ki 4630.0 Preclinical
CHEMBL594918 5.29 Ki 5170.0 Preclinical
CHEMBL593667 5.07 Ki 8510.0 Preclinical
CHEMBL750 5.07 Ki 8510.0 Approved
CHEMBL593759 5.06 Ki 8630.0 Preclinical
CHEMBL595861 5.06 Ki 8720.0 Preclinical
Distribution

pChEMBL Value Distribution

14
5.0
1
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
27
Tested Compounds
1
Assay Types
Binding — 1 assays, 27 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 27 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine