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Target Snapshot

CHEMBL1949488 Target Snapshot

m7GpppX diphosphatase · SINGLE PROTEIN · Homo sapiens

80Compounds
23Assays
0Approved Drugs
62.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q96C86. Use UniProt Q96C86 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q96C86 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats m7GpppX diphosphatase as ChEMBL target CHEMBL1949488, mapped to UniProt Q96C86. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
m7GpppX diphosphatase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1949488
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q96C86
m7GpppX diphosphatase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether m7GpppX diphosphatase is the right protein anchor across sources, using UniProt Q96C86 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Labelm7GpppX diphosphatase
UniProt AccessionQ96C86
Component TypeProtein
Sequence Length337 aa

m7GpppX diphosphatase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as m7GpppX diphosphatase, mapped to UniProt Q96C86. Sequence length is 337 aa.

Mapped IDQ96C86
Review namem7GpppX diphosphatase
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5048.0
KI13.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL251428 10.7 IC50 0.02 Preclinical
CHEMBL251906 10.7 IC50 0.02 Preclinical
CHEMBL251429 10.52 IC50 0.03 Preclinical
CHEMBL4080254 10.52 IC50 0.03 Preclinical
CHEMBL4082618 10.4 IC50 0.04 Preclinical
CHEMBL255019 10.3 IC50 0.05 Preclinical
CHEMBL4072132 10.16 IC50 0.069 Preclinical
CHEMBL1232147 10.1 IC50 0.08 Preclinical
CHEMBL250072 9.96 IC50 0.11 Preclinical
CHEMBL4077061 9.96 IC50 0.11 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
2
5.5
7
6.0
2
6.5
2
7.0
6
7.5
5
8.0
4
8.5
2
9.0
6
9.5
pChEMBL
Assay Landscape

Assay Landscape

23
Total Assays
42
Tested Compounds
2
Assay Types
Binding — 20 assays, 42 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 17 42 7.9
cell-based format 2 0
assay format 1 0
ADME — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 3 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine