Vascular endothelial growth factor receptor 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Vascular endothelial growth factor receptor 3 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 5 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P35916. Start with neoplasm, then reuse UniProt P35916 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P35916 as the stable protein anchor across project notes and exports.
Vascular endothelial growth factor receptor 3 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 5 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include CATEQUENTINIB, FAMITINIB, IMC-3C5, SUNITINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyVascular endothelial growth factor receptor 3
Review this target as Vascular endothelial growth factor receptor 3, mapped to UniProt P35916. Sequence length is 1363 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Vascular endothelial growth factor receptor 3 as ChEMBL target CHEMBL1955, mapped to UniProt P35916. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Vascular endothelial growth factor receptor 3 is the right protein anchor across sources, using UniProt P35916 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 5 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Vascular endothelial growth factor receptor 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P35916 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Vascular endothelial growth factor receptor 3 |
| UniProt Accession | P35916 |
| Component Type | Protein |
| Sequence Length | 1363 aa |
Vascular endothelial growth factor receptor 3
Review this target as Vascular endothelial growth factor receptor 3, mapped to UniProt P35916. Sequence length is 1363 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Vascular endothelial growth factor receptor 3 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include CATEQUENTINIB, FAMITINIB, IMC-3C5, SUNITINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1289926 | 10.0 | IC50 | 0.1 | Approved |
| CHEMBL3939307 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL24828 | 9.96 | IC50 | 0.11 | Approved |
| CHEMBL273187 | 9.9 | Ki | 0.1259 | Preclinical |
| CHEMBL5403470 | 9.74 | IC50 | 0.18 | Preclinical |
| CHEMBL5421802 | 9.74 | IC50 | 0.18 | Preclinical |
| CHEMBL404366 | 9.7 | Ki | 0.1995 | Preclinical |
| CHEMBL1940109 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL1289494 | 9.62 | IC50 | 0.24 | Approved |
| CHEMBL271441 | 9.5 | Ki | 0.3162 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 504 | 441 | 7.2 |
| cell-based format | 64 | 76 | 7.1 |
| assay format | 52 | 23 | 7.1 |
| organism-based format | 6 | 0 | — |
| tissue-based format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 1 | 6.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 321 | 6.6 |