Insulin-like growth factor 1 receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Insulin-like growth factor 1 receptor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 13 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P08069. Start with neoplasm, then reuse UniProt P08069 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P08069 as the stable protein anchor across project notes and exports.
Insulin-like growth factor 1 receptor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 13 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AXL-1717, BIIB-022, BMS-754807, CIXUTUMUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyInsulin-like growth factor 1 receptor
Review this target as Insulin-like growth factor 1 receptor, mapped to UniProt P08069. Sequence length is 1367 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Insulin-like growth factor 1 receptor as ChEMBL target CHEMBL1957, mapped to UniProt P08069. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Insulin-like growth factor 1 receptor is the right protein anchor across sources, using UniProt P08069 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 13 linked drugs in the same disease frame.
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| Preferred Name | Insulin-like growth factor 1 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P08069 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Insulin-like growth factor 1 receptor |
| UniProt Accession | P08069 |
| Component Type | Protein |
| Sequence Length | 1367 aa |
Insulin-like growth factor 1 receptor
Review this target as Insulin-like growth factor 1 receptor, mapped to UniProt P08069. Sequence length is 1367 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Insulin-like growth factor 1 receptor shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AXL-1717, BIIB-022, BMS-754807, CIXUTUMUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3950012 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL3905758 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL3979064 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL3977170 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL3955626 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL3928243 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL3979509 | 10.05 | IC50 | 0.09 | Preclinical |
| CHEMBL3969930 | 10.05 | IC50 | 0.09 | Preclinical |
| CHEMBL3896205 | 10.05 | IC50 | 0.09 | Preclinical |
| CHEMBL3892425 | 10.0 | IC50 | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 753 | 1,584 | 7.3 |
| cell-based format | 170 | 579 | 6.7 |
| assay format | 89 | 568 | 6.9 |
| subcellular format | 8 | 8 | 5.9 |
| cell-free format | 2 | 1 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 47 | 17 | 6.7 |
| assay format | 6 | 119 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |