3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P14060. Use UniProt P14060 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P14060 as the stable identity anchor, then attach disease evidence before program review.
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Review this target as 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1, mapped to UniProt P14060. Sequence length is 373 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 as ChEMBL target CHEMBL1958, mapped to UniProt P14060. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P14060 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 |
| UniProt Accession | P14060 |
| Component Type | Protein |
| Sequence Length | 373 aa |
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Review this target as 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1, mapped to UniProt P14060. Sequence length is 373 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL25516 | 8.11 | Ki | 7.8 | Preclinical |
| CHEMBL24033 | 8.08 | IC50 | 8.3 | Preclinical |
| CHEMBL280155 | 8.0 | Ki | 10.0 | Preclinical |
| CHEMBL297524 | 7.92 | Ki | 12.0 | Preclinical |
| CHEMBL25183 | 7.72 | Ki | 19.0 | Preclinical |
| CHEMBL24088 | 6.82 | Ki | 150.0 | Preclinical |
| CHEMBL24729 | 6.82 | IC50 | 150.0 | Preclinical |
| CHEMBL283123 | 6.8 | Ki | 160.0 | Preclinical |
| CHEMBL3085538 | 6.75 | Ki | 180.0 | Preclinical |
| CHEMBL24291 | 6.72 | Ki | 190.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 15 | 6.9 |