Tyrosinase · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Tyrosinase shows clinical signal disease relevance led by freckles. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P14679. Start with freckles, then reuse UniProt P14679 as the stable protein anchor across project notes and exports.
Start with freckles, then reuse UniProt P14679 as the stable protein anchor across project notes and exports.
Tyrosinase shows clinical signal disease relevance led by freckles. 1 linked drug remains visible in the same block.
Start review with freckles because it currently carries clinical signal support. Linked drugs include ARBUTIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyTyrosinase
Review this target as Tyrosinase, mapped to UniProt P14679. Sequence length is 529 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosinase as ChEMBL target CHEMBL1973, mapped to UniProt P14679. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Tyrosinase is the right protein anchor across sources, using UniProt P14679 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why freckles is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Tyrosinase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P14679 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosinase |
| UniProt Accession | P14679 |
| Component Type | Protein |
| Sequence Length | 529 aa |
Tyrosinase
Review this target as Tyrosinase, mapped to UniProt P14679. Sequence length is 529 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Tyrosinase shows clinical signal disease relevance led by freckles.
Start review with freckles because it currently carries clinical signal support. Linked drugs include ARBUTIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5591296 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL5592150 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL5594635 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL463145 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL24152 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL394855 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL465880 | 7.1 | IC50 | 80.0 | Preclinical |
| CHEMBL43065 | 7.05 | IC50 | 90.0 | Preclinical |
| CHEMBL480477 | 7.05 | IC50 | 90.0 | Preclinical |
| CHEMBL146 | 6.92 | IC50 | 120.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 129 | 189 | 5.3 |
| cell-based format | 67 | 65 | 5.4 |
| subcellular format | 3 | 31 | 4.9 |
| tissue-based format | 2 | 5 | 4.6 |
| assay format | 1 | 1 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 0 | — |