Vitamin D3 receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Vitamin D3 receptor shows approved-linked disease relevance led by psoriasis. 5 more disease programs remain visible in the same review block. 7 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P11473. Start with psoriasis, then reuse UniProt P11473 as the stable protein anchor across project notes and exports.
Start with psoriasis, then reuse UniProt P11473 as the stable protein anchor across project notes and exports.
Vitamin D3 receptor shows approved-linked disease relevance led by psoriasis. 5 more disease programs remain visible in the same review block. 7 linked drugs remain visible in the same block.
Start review with psoriasis because it currently carries approved-linked support. Linked drugs include BECOCALCIDIOL, CALCIPOTRIENE, CALCITRIOL, CHOLECALCIFEROL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyVitamin D3 receptor
Review this target as Vitamin D3 receptor, mapped to UniProt P11473. Sequence length is 427 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Vitamin D3 receptor as ChEMBL target CHEMBL1977, mapped to UniProt P11473. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Vitamin D3 receptor is the right protein anchor across sources, using UniProt P11473 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why psoriasis is currently framed as approved-linked support. It currently carries 7 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Vitamin D3 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11473 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Vitamin D3 receptor |
| UniProt Accession | P11473 |
| Component Type | Protein |
| Sequence Length | 427 aa |
Vitamin D3 receptor
Review this target as Vitamin D3 receptor, mapped to UniProt P11473. Sequence length is 427 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Vitamin D3 receptor shows approved-linked disease relevance led by psoriasis. 5 more disease programs remain visible in the same review block.
Start review with psoriasis because it currently carries approved-linked support. Linked drugs include BECOCALCIDIOL, CALCIPOTRIENE, CALCITRIOL, CHOLECALCIFEROL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2407821 | 11.0 | EC50 | 0.01 | Preclinical |
| CHEMBL846 | 10.97 | EC50 | 0.0106 | Approved |
| CHEMBL4794075 | 10.85 | EC50 | 0.014 | Preclinical |
| CHEMBL467212 | 10.7 | EC50 | 0.02 | Preclinical |
| CHEMBL2058272 | 10.54 | IC50 | 0.029 | Preclinical |
| CHEMBL4159525 | 10.52 | EC50 | 0.03 | Preclinical |
| CHEMBL272304 | 10.4 | EC50 | 0.0396 | Preclinical |
| CHEMBL846 | 10.4 | IC50 | 0.04 | Approved |
| CHEMBL2407824 | 10.36 | EC50 | 0.044 | Preclinical |
| CHEMBL1834893 | 10.22 | EC50 | 0.06 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 302 | 288 | 6.9 |
| single protein format | 120 | 194 | 6.2 |
| assay format | 21 | 43 | 8.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 84 | 115 | 7.7 |
| assay format | 15 | 4 | 8.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |
| single protein format | 1 | 0 | — |