5-hydroxytryptamine receptor 1D · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-145-hydroxytryptamine receptor 1D shows approved-linked disease relevance led by migraine disorder. 5 more disease programs remain visible in the same review block. 10 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P28221. Start with migraine disorder, then reuse UniProt P28221 as the stable protein anchor across project notes and exports.
Start with migraine disorder, then reuse UniProt P28221 as the stable protein anchor across project notes and exports.
5-hydroxytryptamine receptor 1D shows approved-linked disease relevance led by migraine disorder. 5 more disease programs remain visible in the same review block. 10 linked drugs remain visible in the same block.
Start review with migraine disorder because it currently carries approved-linked support. Linked drugs include ALMOTRIPTAN MALATE, DIHYDROERGOTAMINE MESYLATE, ELETRIPTAN HYDROBROMIDE, ERGOTAMINE TARTRATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxy5-hydroxytryptamine receptor 1D
Review this target as 5-hydroxytryptamine receptor 1D, mapped to UniProt P28221. Sequence length is 377 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 1D as ChEMBL target CHEMBL1983, mapped to UniProt P28221. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether 5-hydroxytryptamine receptor 1D is the right protein anchor across sources, using UniProt P28221 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why migraine disorder is currently framed as approved-linked support. It currently carries 10 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | 5-hydroxytryptamine receptor 1D |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P28221 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 1D |
| UniProt Accession | P28221 |
| Component Type | Protein |
| Sequence Length | 377 aa |
5-hydroxytryptamine receptor 1D
Review this target as 5-hydroxytryptamine receptor 1D, mapped to UniProt P28221. Sequence length is 377 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
5-hydroxytryptamine receptor 1D shows approved-linked disease relevance led by migraine disorder. 5 more disease programs remain visible in the same review block.
Start review with migraine disorder because it currently carries approved-linked support. Linked drugs include ALMOTRIPTAN MALATE, DIHYDROERGOTAMINE MESYLATE, ELETRIPTAN HYDROBROMIDE, ERGOTAMINE TARTRATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1242345 | 10.7 | Ki | 0.01995 | Preclinical |
| CHEMBL1242081 | 10.4 | Ki | 0.03981 | Preclinical |
| CHEMBL22744 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL513715 | 10.3 | Ki | 0.05012 | Preclinical |
| CHEMBL1290487 | 10.1 | Ki | 0.07943 | Preclinical |
| CHEMBL469374 | 10.1 | Ki | 0.07943 | Preclinical |
| CHEMBL357478 | 10.05 | Ki | 0.09 | Preclinical |
| CHEMBL112507 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL1241736 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL1241913 | 10.0 | Ki | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 250 | 555 | 7.3 |
| cell-based format | 98 | 648 | 8.0 |
| assay format | 9 | 49 | 6.5 |
| tissue-based format | 6 | 10 | 7.7 |
| cell membrane format | 2 | 0 | — |
| organism-based format | 1 | 1 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 34 | 155 | 8.9 |
| assay format | 29 | 44 | 8.1 |
| tissue-based format | 2 | 5 | 6.5 |
| single protein format | 1 | 1 | 9.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |
| single protein format | 1 | 0 | — |