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Target Snapshot

CHEMBL1992 Target Snapshot

DNA (cytosine-5)-methyltransferase 3A · SINGLE PROTEIN · Homo sapiens

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191Compounds
74Assays
0Approved Drugs
89.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

DNA (cytosine-5)-methyltransferase 3A shows approved-linked disease relevance led by acute myeloid leukemia. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q9Y6K1. Start with acute myeloid leukemia, then reuse UniProt Q9Y6K1 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with acute myeloid leukemia, then reuse UniProt Q9Y6K1 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 2 linked drugs
Open source guide
Disease program
acute myeloid leukemia

DNA (cytosine-5)-methyltransferase 3A shows approved-linked disease relevance led by acute myeloid leukemia. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with acute myeloid leukemia because it currently carries approved-linked support. Linked drugs include AZACITIDINE, DECITABINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats DNA (cytosine-5)-methyltransferase 3A as ChEMBL target CHEMBL1992, mapped to UniProt Q9Y6K1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
DNA (cytosine-5)-methyltransferase 3A
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1992
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9Y6K1
DNA (cytosine-5)-methyltransferase 3A
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether DNA (cytosine-5)-methyltransferase 3A is the right protein anchor across sources, using UniProt Q9Y6K1 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why acute myeloid leukemia is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameDNA (cytosine-5)-methyltransferase 3A
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9Y6K1
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDNA (cytosine-5)-methyltransferase 3A
UniProt AccessionQ9Y6K1
Component TypeProtein
Sequence Length912 aa

DNA (cytosine-5)-methyltransferase 3A

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as DNA (cytosine-5)-methyltransferase 3A, mapped to UniProt Q9Y6K1. Sequence length is 912 aa.

Mapped IDQ9Y6K1
Review nameDNA (cytosine-5)-methyltransferase 3A
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

DNA (cytosine-5)-methyltransferase 3A shows approved-linked disease relevance led by acute myeloid leukemia. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
acute myeloid leukemia
2 linked drugs · 2 direct · 2 efficacy
Linked drugAZACITIDINE
Linked drugDECITABINE
Approved-linked Approved
cancer
2 linked drugs · 2 direct · 2 efficacy
Linked drugAZACITIDINE
Linked drugDECITABINE
Approved-linked Approved
chronic myelomonocytic leukemia
2 linked drugs · 2 direct · 2 efficacy
Linked drugAZACITIDINE
Linked drugDECITABINE
Approved-linked Approved
myelodysplastic syndrome
2 linked drugs · 2 direct · 2 efficacy
Linked drugAZACITIDINE
Linked drugDECITABINE
Approved-linked Approved
myeloid leukemia
2 linked drugs · 2 direct · 2 efficacy
Linked drugAZACITIDINE
Linked drugDECITABINE
Approved-linked Approved
neoplasm
2 linked drugs · 2 direct · 2 efficacy
Linked drugAZACITIDINE
Linked drugDECITABINE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with acute myeloid leukemia because it currently carries approved-linked support. Linked drugs include AZACITIDINE, DECITABINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseacute myeloid leukemia
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Assay Mix

Activity Type Distribution

IC5054.0
KI8.0
EC5027.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4208004 7.04 IC50 92.0 Preclinical
CHEMBL4091463 6.52 EC50 300.0 Preclinical
CHEMBL5285340 6.1 IC50 800.0 Preclinical
CHEMBL2336409 6.05 EC50 900.0 Preclinical
CHEMBL2336409 6.05 IC50 900.0 Preclinical
CHEMBL5276042 6.05 IC50 900.0 Preclinical
CHEMBL4878570 6.03 IC50 930.0 Preclinical
CHEMBL4070517 6.0 EC50 1000.0 Preclinical
CHEMBL4099197 5.96 EC50 1100.0 Preclinical
CHEMBL4097685 5.92 EC50 1200.0 Preclinical
Distribution

pChEMBL Value Distribution

23
5.0
11
5.5
7
6.0
1
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

74
Total Assays
54
Tested Compounds
3
Assay Types
Binding — 72 assays, 54 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 54 46 5.3
cell-based format 15 5 4.8
assay format 3 3 4.3
ADME — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 1 5.1
Functional — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 1 7.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine