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Evidence Snapshot

Plasma kallikrein

CHEMBL2000 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:43:54Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2000
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Plasma kallikrein as ChEMBL target CHEMBL2000, mapped to UniProt P03952. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Plasma kallikrein
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2000
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P03952
Plasma kallikrein
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Plasma kallikrein matters

As of 2026-09-13

Plasma kallikrein is reviewed as Plasma kallikrein (UniProt P03952); Plasma kallikrein shows approved-linked disease relevance led by hereditary angioedema. 5 more disease programs remain visible in the same review block.; 5 linked drugs keep this evidence frame grounded.; the current evidence base includes 2 approved drugs, 5000 compounds, and 286 assays, with lead potency reaching pChEMBL 10.7.

Disease context
hereditary angioedema

Plasma kallikrein shows approved-linked disease relevance led by hereditary angioedema. 5 more disease programs remain visible in the same review block. 5 linked drugs keep the rationale reviewable. 5 additional disease programs remain visible in the same card. Linked drugs include AVORALSTAT, BEROTRALSTAT HYDROCHLORIDE, ECALLANTIDE.

Start review with hereditary angioedema because it currently carries approved-linked support. Linked drugs include AVORALSTAT, BEROTRALSTAT HYDROCHLORIDE, ECALLANTIDE, HUMAN C1-ESTERASE INHIBITOR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Approved-linked 5 linked drugs
Activity base
Portfolio and assay base

ChEMBL currently tracks 2 approved drugs, 5000 compounds, and 286 assays for this target. The dominant activity type is IC50. CHEMBL4471466 is the current potency anchor at pChEMBL 10.7.

Use CHEMBL4471466 as the tractability anchor when discussing potency (pChEMBL 10.7).

Activity source · ChEMBL 36 via Core Engine
2 approved pChEMBL 10.7
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Plasma kallikrein matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P03952, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need to see why hereditary angioedema is currently treated as approved-linked support.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

5000
Total Compounds
286
Total Assays
2
Approved Drugs
IC50: 4974.0, KI: 3789.0, EC50: 413.0, KD: 4.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL4471466
 10.7 Ki —
No preferred name
CHEMBL4238882
 10.7 Ki —
No preferred name
CHEMBL3969639
 10.7 IC50 —
No preferred name
CHEMBL3897372
 10.5 IC50 —
No preferred name
CHEMBL3982813
 10.4 IC50 —

Approved Drugs

Structure Compound First Approval
BEROTRALSTAT
CHEMBL5189739
 2020
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:43:54Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2000