Platelet-derived growth factor receptor alpha · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Platelet-derived growth factor receptor alpha shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 5 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P16234. Start with neoplasm, then reuse UniProt P16234 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P16234 as the stable protein anchor across project notes and exports.
Platelet-derived growth factor receptor alpha shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 5 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AMUVATINIB, AVAPRITINIB, OLARATUMAB, RIPRETINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyPlatelet-derived growth factor receptor alpha
Review this target as Platelet-derived growth factor receptor alpha, mapped to UniProt P16234. Sequence length is 1089 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Platelet-derived growth factor receptor alpha as ChEMBL target CHEMBL2007, mapped to UniProt P16234. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Platelet-derived growth factor receptor alpha is the right protein anchor across sources, using UniProt P16234 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 5 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Platelet-derived growth factor receptor alpha |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P16234 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Platelet-derived growth factor receptor alpha |
| UniProt Accession | P16234 |
| Component Type | Protein |
| Sequence Length | 1089 aa |
Platelet-derived growth factor receptor alpha
Review this target as Platelet-derived growth factor receptor alpha, mapped to UniProt P16234. Sequence length is 1089 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Platelet-derived growth factor receptor alpha shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AMUVATINIB, AVAPRITINIB, OLARATUMAB, RIPRETINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL196363 | 10.1 | Ki | 0.07943 | Preclinical |
| CHEMBL3904768 | 10.05 | IC50 | 0.09 | Preclinical |
| CHEMBL3979322 | 9.74 | IC50 | 0.18 | Preclinical |
| CHEMBL3940697 | 9.72 | IC50 | 0.19 | Preclinical |
| CHEMBL3915941 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL1668411 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL4204794 | 9.62 | IC50 | 0.24 | Approved |
| CHEMBL3913766 | 9.49 | IC50 | 0.32 | Preclinical |
| CHEMBL491473 | 9.39 | Kd | 0.41 | Clinical |
| CHEMBL388978 | 9.38 | IC50 | 0.418 | Preclinical |