Thioredoxin · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Thioredoxin shows clinical signal disease relevance led by pancreatic neoplasm. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P10599. Start with pancreatic neoplasm, then reuse UniProt P10599 as the stable protein anchor across project notes and exports.
Start with pancreatic neoplasm, then reuse UniProt P10599 as the stable protein anchor across project notes and exports.
Thioredoxin shows clinical signal disease relevance led by pancreatic neoplasm. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with pancreatic neoplasm because it currently carries clinical signal support. Linked drugs include PX-12. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyThioredoxin
Review this target as Thioredoxin, mapped to UniProt P10599. Sequence length is 105 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thioredoxin as ChEMBL target CHEMBL2010624, mapped to UniProt P10599. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Thioredoxin is the right protein anchor across sources, using UniProt P10599 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why pancreatic neoplasm is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Thioredoxin |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P10599 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thioredoxin |
| UniProt Accession | P10599 |
| Component Type | Protein |
| Sequence Length | 105 aa |
Thioredoxin
Review this target as Thioredoxin, mapped to UniProt P10599. Sequence length is 105 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Thioredoxin shows clinical signal disease relevance led by pancreatic neoplasm. 1 more disease program remain visible in the same review block.
Start review with pancreatic neoplasm because it currently carries clinical signal support. Linked drugs include PX-12. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2315295 | 7.05 | IC50 | 90.0 | Preclinical |
| CHEMBL2315297 | 6.77 | IC50 | 170.0 | Preclinical |
| CHEMBL2315294 | 6.62 | IC50 | 240.0 | Preclinical |
| CHEMBL2315292 | 6.54 | IC50 | 290.0 | Preclinical |
| CHEMBL2315306 | 6.47 | IC50 | 340.0 | Preclinical |
| CHEMBL2315290 | 6.35 | IC50 | 450.0 | Preclinical |
| CHEMBL2315299 | 6.29 | IC50 | 510.0 | Preclinical |
| CHEMBL2315288 | 6.27 | IC50 | 540.0 | Preclinical |
| CHEMBL406050 | 5.68 | IC50 | 2110.0 | Clinical |
| CHEMBL555017 | 5.51 | Ki | 3110.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 20 | 4 | 5.1 |
| cell-based format | 12 | 10 | 6.3 |
| assay format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |