Coagulation factor IX · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Coagulation factor IX shows approved-linked disease relevance led by hemophilia B. 5 more disease programs remain visible in the same review block. 8 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P00740. Start with hemophilia B, then reuse UniProt P00740 as the stable protein anchor across project notes and exports.
Start with hemophilia B, then reuse UniProt P00740 as the stable protein anchor across project notes and exports.
Coagulation factor IX shows approved-linked disease relevance led by hemophilia B. 5 more disease programs remain visible in the same review block. 8 linked drugs remain visible in the same block.
Start review with hemophilia B because it currently carries approved-linked support. Linked drugs include ALBUTREPENONACOG ALFA, COAGULATION FACTOR IX HUMAN, COAGULATION FACTOR IX RECOMBINANT HUMAN, EFTRENONACOG ALFA. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCoagulation factor IX
Review this target as Coagulation factor IX, mapped to UniProt P00740. Sequence length is 461 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Coagulation factor IX as ChEMBL target CHEMBL2016, mapped to UniProt P00740. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Coagulation factor IX is the right protein anchor across sources, using UniProt P00740 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why hemophilia B is currently framed as approved-linked support. It currently carries 8 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Coagulation factor IX |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P00740 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Coagulation factor IX |
| UniProt Accession | P00740 |
| Component Type | Protein |
| Sequence Length | 461 aa |
Coagulation factor IX
Review this target as Coagulation factor IX, mapped to UniProt P00740. Sequence length is 461 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Coagulation factor IX shows approved-linked disease relevance led by hemophilia B. 5 more disease programs remain visible in the same review block.
Start review with hemophilia B because it currently carries approved-linked support. Linked drugs include ALBUTREPENONACOG ALFA, COAGULATION FACTOR IX HUMAN, COAGULATION FACTOR IX RECOMBINANT HUMAN, EFTRENONACOG ALFA. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4107149 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL4110926 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL4114881 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL4112773 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL4113483 | 10.22 | Ki | 0.06 | Preclinical |
| CHEMBL4109568 | 10.22 | Ki | 0.06 | Preclinical |
| CHEMBL4108033 | 10.15 | Ki | 0.07 | Preclinical |
| CHEMBL4115630 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL4110983 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL3948120 | 10.05 | Ki | 0.09 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 93 | 926 | 7.5 |
| assay format | 1 | 0 | — |
| cell-free format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 13 | 5.8 |