NEDD8-activating enzyme E1 regulatory subunit · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q13564. Use UniProt Q13564 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q13564 as the stable identity anchor, then attach disease evidence before program review.
NEDD8-activating enzyme E1 regulatory subunit
Review this target as NEDD8-activating enzyme E1 regulatory subunit, mapped to UniProt Q13564. Sequence length is 534 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NEDD8-activating enzyme E1 regulatory subunit as ChEMBL target CHEMBL2016431, mapped to UniProt Q13564. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | NEDD8-activating enzyme E1 regulatory subunit |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q13564 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | NEDD8-activating enzyme E1 regulatory subunit |
| UniProt Accession | Q13564 |
| Component Type | Protein |
| Sequence Length | 534 aa |
NEDD8-activating enzyme E1 regulatory subunit
Review this target as NEDD8-activating enzyme E1 regulatory subunit, mapped to UniProt Q13564. Sequence length is 534 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5177755 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL1231160 | 8.4 | IC50 | 4.0 | Clinical |
| CHEMBL5633567 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL2322194 | 8.33 | IC50 | 4.7 | Preclinical |
| CHEMBL2017005 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL4282603 | 6.58 | IC50 | 260.0 | Preclinical |
| CHEMBL2322197 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL4640167 | 5.45 | EC50 | 3560.0 | Preclinical |
| CHEMBL2322196 | 5.3 | IC50 | 5000.0 | Preclinical |
| CHEMBL4788522 | 5.26 | IC50 | 5510.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 53 | 1 | 5.5 |
| single protein format | 20 | 13 | 6.6 |