Sphingolipid delta(4)-desaturase DES1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O15121. Use UniProt O15121 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O15121 as the stable identity anchor, then attach disease evidence before program review.
Sphingolipid delta(4)-desaturase DES1
Review this target as Sphingolipid delta(4)-desaturase DES1, mapped to UniProt O15121. Sequence length is 323 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sphingolipid delta(4)-desaturase DES1 as ChEMBL target CHEMBL2021749, mapped to UniProt O15121. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Sphingolipid delta(4)-desaturase DES1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O15121 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sphingolipid delta(4)-desaturase DES1 |
| UniProt Accession | O15121 |
| Component Type | Protein |
| Sequence Length | 323 aa |
Sphingolipid delta(4)-desaturase DES1
Review this target as Sphingolipid delta(4)-desaturase DES1, mapped to UniProt O15121. Sequence length is 323 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5267102 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5283631 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL6049628 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5898757 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL5982554 | 8.41 | IC50 | 3.9 | Preclinical |
| CHEMBL5280582 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL5958435 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL5758107 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL5844152 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL5996966 | 8.3 | IC50 | 5.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 10 | 41 | 7.3 |
| subcellular format | 3 | 3 | 7.1 |
| single protein format | 2 | 5 | 8.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |