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Target Snapshot

CHEMBL2021750 Target Snapshot

TGF-beta receptor type-1 · SINGLE PROTEIN · Mus musculus

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99Compounds
12Assays
0Approved Drugs
95.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q64729. Use UniProt Q64729 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q64729 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats TGF-beta receptor type-1 as ChEMBL target CHEMBL2021750, mapped to UniProt Q64729. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
TGF-beta receptor type-1
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL2021750
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q64729
TGF-beta receptor type-1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether TGF-beta receptor type-1 is the right protein anchor across sources, using UniProt Q64729 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameTGF-beta receptor type-1
Target TypeSINGLE PROTEIN
OrganismMus musculus
UniProtQ64729
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTGF-beta receptor type-1
UniProt AccessionQ64729
Component TypeProtein
Sequence Length503 aa

TGF-beta receptor type-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as TGF-beta receptor type-1, mapped to UniProt Q64729. Sequence length is 503 aa.

Mapped IDQ64729
Review nameTGF-beta receptor type-1
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5043.0
KI1.0
EC5051.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4514379 8.85 Ki 1.4 Preclinical
CHEMBL3260567 7.92 IC50 12.1 Clinical
CHEMBL5557584 7.82 EC50 15.3 Preclinical
CHEMBL4788502 7.55 IC50 28.4 Preclinical
CHEMBL4777871 7.54 IC50 28.9 Preclinical
CHEMBL5559089 7.53 EC50 29.6 Preclinical
CHEMBL4791815 7.37 IC50 42.5 Preclinical
CHEMBL2024685 7.36 IC50 44.0 Preclinical
CHEMBL492634 7.36 IC50 44.2 Preclinical
CHEMBL2024693 7.34 IC50 46.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
2
5.5
25
6.0
27
6.5
17
7.0
5
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

12
Total Assays
78
Tested Compounds
2
Assay Types
Binding — 8 assays, 78 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 77 6.7
single protein format 1 0 —
tissue-based format 1 1 8.8
ADME — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0 —
single protein format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine