Catechol O-methyltransferase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Catechol O-methyltransferase shows approved-linked disease relevance led by Parkinson disease. 5 more disease programs remain visible in the same review block. 4 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P21964. Start with Parkinson disease, then reuse UniProt P21964 as the stable protein anchor across project notes and exports.
Start with Parkinson disease, then reuse UniProt P21964 as the stable protein anchor across project notes and exports.
Catechol O-methyltransferase shows approved-linked disease relevance led by Parkinson disease. 5 more disease programs remain visible in the same review block. 4 linked drugs remain visible in the same block.
Start review with Parkinson disease because it currently carries approved-linked support. Linked drugs include ENTACAPONE, NEBICAPONE, OPICAPONE, TOLCAPONE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCatechol O-methyltransferase
Review this target as Catechol O-methyltransferase, mapped to UniProt P21964. Sequence length is 271 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Catechol O-methyltransferase as ChEMBL target CHEMBL2023, mapped to UniProt P21964. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Catechol O-methyltransferase is the right protein anchor across sources, using UniProt P21964 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Parkinson disease is currently framed as approved-linked support. It currently carries 4 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Catechol O-methyltransferase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P21964 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Catechol O-methyltransferase |
| UniProt Accession | P21964 |
| Component Type | Protein |
| Sequence Length | 271 aa |
Catechol O-methyltransferase
Review this target as Catechol O-methyltransferase, mapped to UniProt P21964. Sequence length is 271 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Catechol O-methyltransferase shows approved-linked disease relevance led by Parkinson disease. 5 more disease programs remain visible in the same review block.
Start review with Parkinson disease because it currently carries approved-linked support. Linked drugs include ENTACAPONE, NEBICAPONE, OPICAPONE, TOLCAPONE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1089318 | 9.0 | Ki | 1.0 | Approved |
| CHEMBL1091204 | 8.96 | Ki | 1.1 | Preclinical |
| CHEMBL1089630 | 8.89 | Ki | 1.3 | Preclinical |
| CHEMBL1091983 | 8.8 | Ki | 1.6 | Preclinical |
| CHEMBL4167128 | 8.7 | IC50 | 1.995 | Preclinical |
| CHEMBL4174978 | 8.7 | IC50 | 1.995 | Preclinical |
| CHEMBL1089504 | 8.66 | Ki | 2.2 | Preclinical |
| CHEMBL4170443 | 8.5 | IC50 | 3.162 | Preclinical |
| CHEMBL4171117 | 8.4 | IC50 | 3.981 | Preclinical |
| CHEMBL4172614 | 8.4 | IC50 | 3.981 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 33 | 57 | 6.4 |
| cell-based format | 9 | 69 | 6.7 |
| assay format | 5 | 47 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 0 | — |
| single protein format | 3 | 0 | — |
| cell-based format | 1 | 0 | — |