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Target Snapshot

CHEMBL2024 Target Snapshot

Follicle-stimulating hormone receptor · SINGLE PROTEIN · Homo sapiens

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160Compounds
43Assays
0Approved Drugs
172.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Follicle-stimulating hormone receptor shows approved-linked disease relevance led by infertility. 5 more disease programs remain visible in the same review block. 7 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P23945. Start with infertility, then reuse UniProt P23945 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with infertility, then reuse UniProt P23945 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 7 linked drugs
Open source guide
Disease program
infertility

Follicle-stimulating hormone receptor shows approved-linked disease relevance led by infertility. 5 more disease programs remain visible in the same review block. 7 linked drugs remain visible in the same block.

Start review with infertility because it currently carries approved-linked support. Linked drugs include CORIFOLLITROPIN ALFA, FOLLITROPIN, FOLLITROPIN ALFA, FOLLITROPIN BETA. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 7 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Follicle-stimulating hormone receptor as ChEMBL target CHEMBL2024, mapped to UniProt P23945. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Follicle-stimulating hormone receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2024
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P23945
Follicle-stimulating hormone receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Follicle-stimulating hormone receptor is the right protein anchor across sources, using UniProt P23945 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why infertility is currently framed as approved-linked support. It currently carries 7 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameFollicle-stimulating hormone receptor
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP23945
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFollicle-stimulating hormone receptor
UniProt AccessionP23945
Component TypeProtein
Sequence Length695 aa

Follicle-stimulating hormone receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Follicle-stimulating hormone receptor, mapped to UniProt P23945. Sequence length is 695 aa.

Mapped IDP23945
Review nameFollicle-stimulating hormone receptor
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Follicle-stimulating hormone receptor shows approved-linked disease relevance led by infertility. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
infertility
7 linked drugs · 7 direct · 7 efficacy
Linked drugCORIFOLLITROPIN ALFA
Linked drugFOLLITROPIN
Linked drugFOLLITROPIN ALFA
Linked drugFOLLITROPIN BETA
Approved-linked Approved
anovulation
4 linked drugs · 4 direct · 4 efficacy
Linked drugFOLLITROPIN
Linked drugFOLLITROPIN ALFA
Linked drugFOLLITROPIN DELTA
Linked drugUROFOLLITROPIN
Approved-linked Approved
female infertility
4 linked drugs · 4 direct · 4 efficacy
Linked drugFOLLITROPIN
Linked drugFOLLITROPIN ALFA
Linked drugMENOTROPINS
Linked drugUROFOLLITROPIN
Approved-linked Approved
hypogonadotropic hypogonadism
4 linked drugs · 4 direct · 4 efficacy
Linked drugCORIFOLLITROPIN ALFA
Linked drugFOLLITROPIN
Linked drugFOLLITROPIN ALFA
Linked drugFOLLITROPIN BETA
Approved-linked Approved
hypogonadism
3 linked drugs · 3 direct · 3 efficacy
Linked drugCORIFOLLITROPIN ALFA
Linked drugFOLLITROPIN
Linked drugMENOTROPINS
Approved-linked Approved
male infertility
3 linked drugs · 3 direct · 3 efficacy
Linked drugFOLLITROPIN
Linked drugFOLLITROPIN ALFA
Linked drugUROFOLLITROPIN
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with infertility because it currently carries approved-linked support. Linked drugs include CORIFOLLITROPIN ALFA, FOLLITROPIN, FOLLITROPIN ALFA, FOLLITROPIN BETA. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseinfertility
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Assay Mix

Activity Type Distribution

IC5083.0
EC5089.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2216803 9.0 EC50 1.0 Preclinical
CHEMBL295895 8.92 EC50 1.2 Preclinical
CHEMBL45770 8.77 EC50 1.7 Preclinical
CHEMBL47953 8.74 EC50 1.8 Preclinical
CHEMBL433263 8.57 EC50 2.7 Preclinical
CHEMBL300022 8.52 EC50 3.0 Preclinical
CHEMBL48030 8.44 EC50 3.6 Preclinical
CHEMBL192135 8.4 IC50 4.0 Preclinical
CHEMBL360981 8.3 IC50 5.0 Preclinical
CHEMBL436481 8.3 IC50 5.0 Preclinical
Distribution

pChEMBL Value Distribution

18
5.0
16
5.5
17
6.0
12
6.5
16
7.0
13
7.5
12
8.0
5
8.5
1
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

43
Total Assays
91
Tested Compounds
2
Assay Types
Functional — 26 assays, 91 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 19 63 6.6
assay format 7 28 7.0
Binding — 17 assays, 40 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 10 12 6.2
cell-based format 7 28 6.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine