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Target Snapshot

CHEMBL2027 Target Snapshot

NPC1-like intracellular cholesterol transporter 1 · SINGLE PROTEIN · Homo sapiens

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259Compounds
26Assays
1Approved Drugs
169.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

NPC1-like intracellular cholesterol transporter 1 shows approved-linked disease relevance led by cardiovascular disease. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q9UHC9. Start with cardiovascular disease, then reuse UniProt Q9UHC9 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with cardiovascular disease, then reuse UniProt Q9UHC9 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
cardiovascular disease

NPC1-like intracellular cholesterol transporter 1 shows approved-linked disease relevance led by cardiovascular disease. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with cardiovascular disease because it currently carries approved-linked support. Linked drugs include EZETIMIBE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NPC1-like intracellular cholesterol transporter 1 as ChEMBL target CHEMBL2027, mapped to UniProt Q9UHC9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NPC1-like intracellular cholesterol transporter 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2027
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9UHC9
NPC1-like intracellular cholesterol transporter 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NPC1-like intracellular cholesterol transporter 1 is the right protein anchor across sources, using UniProt Q9UHC9 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why cardiovascular disease is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameNPC1-like intracellular cholesterol transporter 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9UHC9
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNPC1-like intracellular cholesterol transporter 1
UniProt AccessionQ9UHC9
Component TypeProtein
Sequence Length1359 aa

NPC1-like intracellular cholesterol transporter 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NPC1-like intracellular cholesterol transporter 1, mapped to UniProt Q9UHC9. Sequence length is 1359 aa.

Mapped IDQ9UHC9
Review nameNPC1-like intracellular cholesterol transporter 1
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

NPC1-like intracellular cholesterol transporter 1 shows approved-linked disease relevance led by cardiovascular disease. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
cardiovascular disease
1 linked drug · 1 direct · 1 efficacy
Linked drugEZETIMIBE
Approved-linked Approved
familial hypercholesterolemia
1 linked drug · 1 direct · 1 efficacy
Linked drugEZETIMIBE
Approved-linked Approved
homozygous familial hypercholesterolemia
1 linked drug · 1 direct · 1 efficacy
Linked drugEZETIMIBE
Approved-linked Approved
Hypercholesterolemia
1 linked drug · 1 direct · 1 efficacy
Linked drugEZETIMIBE
Approved-linked Approved
hyperlipidemia
1 linked drug · 1 direct · 1 efficacy
Linked drugEZETIMIBE
Late clinical Phase III
Aortic valve stenosis
1 linked drug · 1 direct · 1 efficacy
Linked drugEZETIMIBE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with cardiovascular disease because it currently carries approved-linked support. Linked drugs include EZETIMIBE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasecardiovascular disease
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC50136.0
EC5033.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL578400 8.4 IC50 4.0 Preclinical
CHEMBL504066 8.15 IC50 7.0 Preclinical
CHEMBL3311502 7.07 EC50 86.0 Preclinical
CHEMBL3311372 6.82 EC50 150.0 Preclinical
CHEMBL578401 6.82 IC50 150.0 Preclinical
CHEMBL3311373 6.54 EC50 290.0 Preclinical
CHEMBL321017 6.52 IC50 300.0 Preclinical
CHEMBL3311374 6.44 EC50 360.0 Preclinical
CHEMBL3311500 6.44 EC50 360.0 Preclinical
CHEMBL1138 6.43 IC50 370.0 Approved
Distribution

pChEMBL Value Distribution

54
5.0
27
5.5
14
6.0
6
6.5
1
7.0
1
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

EZETIMIBE
CHEMBL1138
Approved 2002
Properties Compare Identifier
Assay Landscape

Assay Landscape

26
Total Assays
135
Tested Compounds
1
Assay Types
Binding — 26 assays, 135 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 19 128 5.4
single protein format 5 1 6.4
assay format 2 6 6.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine