Somatostatin receptor type 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Somatostatin receptor type 3 shows approved-linked disease relevance led by acromegaly. 3 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P32745. Start with acromegaly, then reuse UniProt P32745 as the stable protein anchor across project notes and exports.
Start with acromegaly, then reuse UniProt P32745 as the stable protein anchor across project notes and exports.
Somatostatin receptor type 3 shows approved-linked disease relevance led by acromegaly. 3 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with acromegaly because it currently carries approved-linked support. Linked drugs include PASIREOTIDE DIASPARTATE, PASIREOTIDE PAMOATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySomatostatin receptor type 3
Review this target as Somatostatin receptor type 3, mapped to UniProt P32745. Sequence length is 418 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Somatostatin receptor type 3 as ChEMBL target CHEMBL2028, mapped to UniProt P32745. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Somatostatin receptor type 3 is the right protein anchor across sources, using UniProt P32745 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why acromegaly is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Somatostatin receptor type 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P32745 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Somatostatin receptor type 3 |
| UniProt Accession | P32745 |
| Component Type | Protein |
| Sequence Length | 418 aa |
Somatostatin receptor type 3
Review this target as Somatostatin receptor type 3, mapped to UniProt P32745. Sequence length is 418 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Somatostatin receptor type 3 shows approved-linked disease relevance led by acromegaly. 3 more disease programs remain visible in the same review block.
Start review with acromegaly because it currently carries approved-linked support. Linked drugs include PASIREOTIDE DIASPARTATE, PASIREOTIDE PAMOATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL440072 | 10.49 | Kd | 0.032 | Preclinical |
| CHEMBL1823872 | 10.0 | Ki | 0.1 | Clinical |
| CHEMBL3323076 | 9.82 | IC50 | 0.15 | Preclinical |
| CHEMBL1824052 | 9.64 | EC50 | 0.23 | Preclinical |
| CHEMBL5193727 | 9.6 | EC50 | 0.249 | Preclinical |
| CHEMBL5190457 | 9.56 | EC50 | 0.276 | Preclinical |
| CHEMBL3582344 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3349606 | 9.5 | Ki | 0.3162 | Preclinical |
| CHEMBL1824051 | 9.46 | EC50 | 0.35 | Preclinical |
| CHEMBL1823872 | 9.4 | IC50 | 0.4 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 48 | 385 | 6.8 |
| cell-based format | 39 | 367 | 7.6 |
| assay format | 8 | 38 | 5.8 |
| cell membrane format | 2 | 45 | 6.9 |
| cell-free format | 1 | 10 | 8.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 27 | 158 | 7.7 |
| assay format | 2 | 3 | 8.0 |
| single protein format | 1 | 39 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |