Prothrombin · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Prothrombin shows approved-linked disease relevance led by Recurrent thrombophlebitis. 5 more disease programs remain visible in the same review block. 6 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P00734. Start with Recurrent thrombophlebitis, then reuse UniProt P00734 as the stable protein anchor across project notes and exports.
Start with Recurrent thrombophlebitis, then reuse UniProt P00734 as the stable protein anchor across project notes and exports.
Prothrombin shows approved-linked disease relevance led by Recurrent thrombophlebitis. 5 more disease programs remain visible in the same review block. 6 linked drugs remain visible in the same block.
Start review with Recurrent thrombophlebitis because it currently carries approved-linked support. Linked drugs include ARGATROBAN, BIVALIRUDIN, DEFIBROTIDE, DESIRUDIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProthrombin
Review this target as Prothrombin, mapped to UniProt P00734. Sequence length is 622 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Prothrombin as ChEMBL target CHEMBL204, mapped to UniProt P00734. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Prothrombin is the right protein anchor across sources, using UniProt P00734 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Recurrent thrombophlebitis is currently framed as approved-linked support. It currently carries 6 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Prothrombin |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P00734 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Prothrombin |
| UniProt Accession | P00734 |
| Component Type | Protein |
| Sequence Length | 622 aa |
Prothrombin
Review this target as Prothrombin, mapped to UniProt P00734. Sequence length is 622 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Prothrombin shows approved-linked disease relevance led by Recurrent thrombophlebitis. 5 more disease programs remain visible in the same review block.
Start review with Recurrent thrombophlebitis because it currently carries approved-linked support. Linked drugs include ARGATROBAN, BIVALIRUDIN, DEFIBROTIDE, DESIRUDIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL121212 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL120079 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL4108739 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL285285 | 10.96 | Ki | 0.011 | Preclinical |
| CHEMBL323583 | 10.89 | Ki | 0.013 | Preclinical |
| CHEMBL330949 | 10.89 | Ki | 0.013 | Preclinical |
| CHEMBL1159688 | 10.82 | Ki | 0.015 | Preclinical |
| CHEMBL124300 | 10.82 | Ki | 0.015 | Preclinical |
| CHEMBL119877 | 10.82 | Ki | 0.015 | Preclinical |
| CHEMBL420540 | 10.82 | Ki | 0.015 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1,087 | 5,398 | 6.7 |
| cell-free format | 23 | 90 | 7.3 |
| assay format | 19 | 53 | 7.7 |
| cell-based format | 10 | 21 | 6.2 |
| tissue-based format | 2 | 8 | 8.3 |
| organism-based format | 1 | 1 | 7.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 28 | 274 | 6.2 |
| cell-free format | 9 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 10 | 13 | 5.9 |
| cell-based format | 2 | 16 | 5.2 |
| cell-free format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |