Thrombin · SINGLE PROTEIN · Oryctolagus cuniculus
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As of 2026-09-13Protein identity stays anchored to UniProt Q28731. Use UniProt Q28731 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q28731 as the stable identity anchor, then attach disease evidence before program review.
Thrombin
Review this target as Thrombin, mapped to UniProt Q28731. Sequence length is 235 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thrombin as ChEMBL target CHEMBL2040703, mapped to UniProt Q28731. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Thrombin is the right protein anchor across sources, using UniProt Q28731 as the stable mapping.
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| Preferred Name | Thrombin |
| Target Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
| UniProt | Q28731 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thrombin |
| UniProt Accession | Q28731 |
| Component Type | Protein |
| Sequence Length | 235 aa |
Thrombin
Review this target as Thrombin, mapped to UniProt Q28731. Sequence length is 235 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4763593 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL539697 | 6.26 | IC50 | 554.0 | Approved |
| CHEMBL3935798 | 5.71 | IC50 | 1950.0 | Preclinical |
| CHEMBL3960020 | 5.09 | IC50 | 8160.0 | Preclinical |
| CHEMBL3909953 | 4.6 | IC50 | 25300.0 | Preclinical |
| CHEMBL3979276 | 4.05 | IC50 | 88200.0 | Preclinical |
| CHEMBL3899919 | 4.04 | IC50 | 91500.0 | Preclinical |
| CHEMBL3971094 | 4.04 | IC50 | 91200.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 0 | — |
| cell-free format | 2 | 9 | 5.2 |