Bile acid receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Bile acid receptor shows approved-linked disease relevance led by primary biliary cirrhosis. 5 more disease programs remain visible in the same review block. 4 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q96RI1. Start with primary biliary cirrhosis, then reuse UniProt Q96RI1 as the stable protein anchor across project notes and exports.
Start with primary biliary cirrhosis, then reuse UniProt Q96RI1 as the stable protein anchor across project notes and exports.
Bile acid receptor shows approved-linked disease relevance led by primary biliary cirrhosis. 5 more disease programs remain visible in the same review block. 4 linked drugs remain visible in the same block.
Start review with primary biliary cirrhosis because it currently carries approved-linked support. Linked drugs include CILOFEXOR, OBETICHOLIC ACID, TROPIFEXOR, URSODIOL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyBile acid receptor
Review this target as Bile acid receptor, mapped to UniProt Q96RI1. Sequence length is 486 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Bile acid receptor as ChEMBL target CHEMBL2047, mapped to UniProt Q96RI1. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Bile acid receptor is the right protein anchor across sources, using UniProt Q96RI1 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why primary biliary cirrhosis is currently framed as approved-linked support. It currently carries 4 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Bile acid receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q96RI1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Bile acid receptor |
| UniProt Accession | Q96RI1 |
| Component Type | Protein |
| Sequence Length | 486 aa |
Bile acid receptor
Review this target as Bile acid receptor, mapped to UniProt Q96RI1. Sequence length is 486 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Bile acid receptor shows approved-linked disease relevance led by primary biliary cirrhosis. 5 more disease programs remain visible in the same review block.
Start review with primary biliary cirrhosis because it currently carries approved-linked support. Linked drugs include CILOFEXOR, OBETICHOLIC ACID, TROPIFEXOR, URSODIOL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4783205 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL4453417 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL4169596 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL4749439 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL4162312 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL5269567 | 10.05 | EC50 | 0.09 | Preclinical |
| CHEMBL4783777 | 10.05 | IC50 | 0.09 | Preclinical |
| CHEMBL5559067 | 10.0 | EC50 | 0.1 | Preclinical |
| CHEMBL5559957 | 10.0 | EC50 | 0.1 | Preclinical |
| CHEMBL6022184 | 10.0 | EC50 | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 556 | 2,047 | 6.5 |
| single protein format | 253 | 1,239 | 6.9 |
| assay format | 29 | 70 | 6.1 |
| organism-based format | 5 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 128 | 257 | 6.4 |
| assay format | 26 | 89 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 2 | 5.1 |