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Target Snapshot

CHEMBL2052031 Target Snapshot

Peptidyl-prolyl cis-trans isomerase FKBP5 · SINGLE PROTEIN · Homo sapiens

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324Compounds
38Assays
4Approved Drugs
418.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-15

Protein identity stays anchored to UniProt Q13451. Use UniProt Q13451 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q13451 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-15
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Peptidyl-prolyl cis-trans isomerase FKBP5 as ChEMBL target CHEMBL2052031, mapped to UniProt Q13451. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Peptidyl-prolyl cis-trans isomerase FKBP5
SINGLE PROTEIN · Homo sapiens
As of 2026-09-15
ChEMBL target ID
CHEMBL2052031
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-15
www.ebi.ac.uk
UniProt accession
Q13451
Peptidyl-prolyl cis-trans isomerase FKBP5
UniProt accession via ChEMBL component mapping As of 2026-09-15
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-15
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Peptidyl-prolyl cis-trans isomerase FKBP5 is the right protein anchor across sources, using UniProt Q13451 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamePeptidyl-prolyl cis-trans isomerase FKBP5
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ13451
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPeptidyl-prolyl cis-trans isomerase FKBP5
UniProt AccessionQ13451
Component TypeProtein
Sequence Length457 aa

Peptidyl-prolyl cis-trans isomerase FKBP5

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Peptidyl-prolyl cis-trans isomerase FKBP5, mapped to UniProt Q13451. Sequence length is 457 aa.

Mapped IDQ13451
Review namePeptidyl-prolyl cis-trans isomerase FKBP5
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5091.0
KI138.0
KD189.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL413 8.52 Ki 3.0 Approved
CHEMBL413 8.43 Kd 3.7 Approved
CHEMBL3623612 8.4 Ki 4.0 Preclinical
CHEMBL5286207 8.4 Ki 4.0 Preclinical
CHEMBL5414438 8.4 Ki 4.0 Preclinical
CHEMBL4871144 8.3 Kd 5.0 Preclinical
CHEMBL5419523 8.3 Ki 5.0 Preclinical
CHEMBL3623630 8.22 Kd 6.0 Preclinical
CHEMBL3623630 8.22 Ki 6.0 Preclinical
CHEMBL5281156 8.22 Ki 6.0 Preclinical
Distribution

pChEMBL Value Distribution

52
5.0
31
5.5
30
6.0
27
6.5
58
7.0
14
7.5
22
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

SIROLIMUS
CHEMBL413
Approved 1999
Properties Compare Identifier
TACROLIMUS ANHYDROUS
CHEMBL269732
Approved 1994
Properties Compare Identifier
Assay Landscape

Assay Landscape

38
Total Assays
254
Tested Compounds
1
Assay Types
Binding — 38 assays, 254 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 26 181 6.1
assay format 8 20 5.3
cell-based format 4 53 6.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine