Dihydrofolate reductase · SINGLE PROTEIN · Pneumocystis jirovecii
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As of 2026-09-14Protein identity stays anchored to UniProt Q9UUP5. Use UniProt Q9UUP5 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9UUP5 as the stable identity anchor, then attach disease evidence before program review.
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt Q9UUP5. Sequence length is 206 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrofolate reductase as ChEMBL target CHEMBL2057, mapped to UniProt Q9UUP5. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dihydrofolate reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Pneumocystis jirovecii |
| UniProt | Q9UUP5 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrofolate reductase |
| UniProt Accession | Q9UUP5 |
| Component Type | Protein |
| Sequence Length | 206 aa |
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt Q9UUP5. Sequence length is 206 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4227124 | 7.46 | IC50 | 35.0 | Preclinical |
| CHEMBL7492 | 7.39 | IC50 | 41.0 | Clinical |
| CHEMBL4228488 | 7.14 | IC50 | 73.0 | Preclinical |
| CHEMBL4227384 | 7.13 | IC50 | 74.0 | Preclinical |
| CHEMBL4226262 | 7.09 | IC50 | 81.0 | Preclinical |
| CHEMBL4228228 | 7.08 | IC50 | 84.0 | Preclinical |
| CHEMBL22 | 7.04 | IC50 | 92.0 | Approved |
| CHEMBL227065 | 7.0 | IC50 | 101.0 | Preclinical |
| CHEMBL4225860 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL4227373 | 6.89 | IC50 | 130.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 20 | 6.9 |