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Target Snapshot

CHEMBL2058 Target Snapshot

B-lymphocyte antigen CD20 · SINGLE PROTEIN · Homo sapiens

0Compounds
0Assays
0Approved Drugs
0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

B-lymphocyte antigen CD20 shows approved-linked disease relevance led by non-Hodgkins lymphoma. 5 more disease programs remain visible in the same review block. 15 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P11836. Start with non-Hodgkins lymphoma, then reuse UniProt P11836 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with non-Hodgkins lymphoma, then reuse UniProt P11836 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 15 linked drugs
Open source guide
Disease program
non-Hodgkins lymphoma

B-lymphocyte antigen CD20 shows approved-linked disease relevance led by non-Hodgkins lymphoma. 5 more disease programs remain visible in the same review block. 15 linked drugs remain visible in the same block.

Start review with non-Hodgkins lymphoma because it currently carries approved-linked support. Linked drugs include EPCORITAMAB, GLOFITAMAB, MOSUNETUZUMAB, MT-3724. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 15 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats B-lymphocyte antigen CD20 as ChEMBL target CHEMBL2058, mapped to UniProt P11836. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
B-lymphocyte antigen CD20
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2058
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P11836
B-lymphocyte antigen CD20
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether B-lymphocyte antigen CD20 is the right protein anchor across sources, using UniProt P11836 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why non-Hodgkins lymphoma is currently framed as approved-linked support. It currently carries 15 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelB-lymphocyte antigen CD20
UniProt AccessionP11836
Component TypeProtein
Sequence Length297 aa

B-lymphocyte antigen CD20

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as B-lymphocyte antigen CD20, mapped to UniProt P11836. Sequence length is 297 aa.

Mapped IDP11836
Review nameB-lymphocyte antigen CD20
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

B-lymphocyte antigen CD20 shows approved-linked disease relevance led by non-Hodgkins lymphoma. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
non-Hodgkins lymphoma
15 linked drugs · 15 direct · 15 efficacy
Linked drugEPCORITAMAB
Linked drugGLOFITAMAB
Linked drugMOSUNETUZUMAB
Linked drugMT-3724
Approved-linked Approved
chronic lymphocytic leukemia
13 linked drugs · 13 direct · 13 efficacy
Linked drugEPCORITAMAB
Linked drugLFB-R603
Linked drugMOSUNETUZUMAB
Linked drugMT-3724
Approved-linked Approved
diffuse large B-cell lymphoma
12 linked drugs · 12 direct · 12 efficacy
Linked drugEPCORITAMAB
Linked drugGLOFITAMAB
Linked drugMOSUNETUZUMAB
Linked drugMT-3724
Approved-linked Approved
follicular lymphoma
11 linked drugs · 11 direct · 11 efficacy
Linked drugEPCORITAMAB
Linked drugMOSUNETUZUMAB
Linked drugOBINUTUZUMAB
Linked drugODRONEXTAMAB
Approved-linked Approved
neoplasm of mature B-cells
11 linked drugs · 11 direct · 11 efficacy
Linked drugEPCORITAMAB
Linked drugGLOFITAMAB
Linked drugMOSUNETUZUMAB
Linked drugMT-3724
Approved-linked Approved
neoplasm
7 linked drugs · 7 direct · 7 efficacy
Linked drugEPCORITAMAB
Linked drugGLOFITAMAB
Linked drugMOSUNETUZUMAB
Linked drugOBINUTUZUMAB
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with non-Hodgkins lymphoma because it currently carries approved-linked support. Linked drugs include EPCORITAMAB, GLOFITAMAB, MOSUNETUZUMAB, MT-3724. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasenon-Hodgkins lymphoma
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine