Ceramide glucosyltransferase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Ceramide glucosyltransferase shows approved-linked disease relevance led by Gaucher disease. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q16739. Start with Gaucher disease, then reuse UniProt Q16739 as the stable protein anchor across project notes and exports.
Start with Gaucher disease, then reuse UniProt Q16739 as the stable protein anchor across project notes and exports.
Ceramide glucosyltransferase shows approved-linked disease relevance led by Gaucher disease. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.
Start review with Gaucher disease because it currently carries approved-linked support. Linked drugs include ELIGLUSTAT TARTRATE, MIGLUSTAT, VENGLUSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCeramide glucosyltransferase
Review this target as Ceramide glucosyltransferase, mapped to UniProt Q16739. Sequence length is 394 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Ceramide glucosyltransferase as ChEMBL target CHEMBL2063, mapped to UniProt Q16739. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Ceramide glucosyltransferase is the right protein anchor across sources, using UniProt Q16739 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Gaucher disease is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Ceramide glucosyltransferase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q16739 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Ceramide glucosyltransferase |
| UniProt Accession | Q16739 |
| Component Type | Protein |
| Sequence Length | 394 aa |
Ceramide glucosyltransferase
Review this target as Ceramide glucosyltransferase, mapped to UniProt Q16739. Sequence length is 394 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Ceramide glucosyltransferase shows approved-linked disease relevance led by Gaucher disease. 5 more disease programs remain visible in the same review block.
Start review with Gaucher disease because it currently carries approved-linked support. Linked drugs include ELIGLUSTAT TARTRATE, MIGLUSTAT, VENGLUSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5182897 | 10.7 | EC50 | 0.02 | Preclinical |
| CHEMBL5170109 | 10.68 | EC50 | 0.021 | Preclinical |
| CHEMBL5191157 | 10.64 | EC50 | 0.023 | Preclinical |
| CHEMBL5177098 | 10.36 | EC50 | 0.044 | Preclinical |
| CHEMBL5195638 | 10.36 | EC50 | 0.044 | Preclinical |
| CHEMBL5197108 | 10.33 | EC50 | 0.047 | Preclinical |
| CHEMBL5286071 | 10.0 | EC50 | 0.1 | Preclinical |
| CHEMBL5413252 | 10.0 | EC50 | 0.1 | Preclinical |
| CHEMBL5414358 | 10.0 | EC50 | 0.1 | Preclinical |
| CHEMBL5415069 | 10.0 | EC50 | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 23 | 90 | 7.9 |
| single protein format | 14 | 182 | 7.1 |
| assay format | 3 | 63 | 7.7 |
| subcellular format | 1 | 6 | 9.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 7.5 |
| tissue-based format | 1 | 1 | 8.1 |