Gamma-aminobutyric acid type B receptor subunit 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Gamma-aminobutyric acid type B receptor subunit 1 shows clinical signal disease relevance led by gastroesophageal reflux disease. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q9UBS5. Start with gastroesophageal reflux disease, then reuse UniProt Q9UBS5 as the stable protein anchor across project notes and exports.
Start with gastroesophageal reflux disease, then reuse UniProt Q9UBS5 as the stable protein anchor across project notes and exports.
Gamma-aminobutyric acid type B receptor subunit 1 shows clinical signal disease relevance led by gastroesophageal reflux disease. 1 linked drug remains visible in the same block.
Start review with gastroesophageal reflux disease because it currently carries clinical signal support. Linked drugs include LESOGABERAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyGamma-aminobutyric acid type B receptor subunit 1
Review this target as Gamma-aminobutyric acid type B receptor subunit 1, mapped to UniProt Q9UBS5. Sequence length is 961 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Gamma-aminobutyric acid type B receptor subunit 1 as ChEMBL target CHEMBL2064, mapped to UniProt Q9UBS5. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Gamma-aminobutyric acid type B receptor subunit 1 is the right protein anchor across sources, using UniProt Q9UBS5 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why gastroesophageal reflux disease is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Gamma-aminobutyric acid type B receptor subunit 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9UBS5 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid type B receptor subunit 1 |
| UniProt Accession | Q9UBS5 |
| Component Type | Protein |
| Sequence Length | 961 aa |
Gamma-aminobutyric acid type B receptor subunit 1
Review this target as Gamma-aminobutyric acid type B receptor subunit 1, mapped to UniProt Q9UBS5. Sequence length is 961 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Gamma-aminobutyric acid type B receptor subunit 1 shows clinical signal disease relevance led by gastroesophageal reflux disease.
Start review with gastroesophageal reflux disease because it currently carries clinical signal support. Linked drugs include LESOGABERAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2391908 | 8.54 | Ki | 2.9 | Preclinical |
| CHEMBL2391908 | 8.19 | IC50 | 6.4 | Preclinical |
| CHEMBL392394 | 7.1 | EC50 | 79.43 | Preclinical |
| CHEMBL96 | 5.77 | EC50 | 1700.0 | Preclinical |
| CHEMBL504482 | 4.29 | EC50 | 51000.0 | Preclinical |
| CHEMBL447171 | 4.28 | EC50 | 52200.0 | Preclinical |
| CHEMBL445449 | 4.14 | EC50 | 71900.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 22 | 0 | — |
| cell-based format | 13 | 2 | 7.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 5 | 4.6 |