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Target Snapshot

CHEMBL2065 Target Snapshot

Beta-lactamase TEM · SINGLE PROTEIN · Escherichia coli

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294Compounds
85Assays
8Approved Drugs
262.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P62593. Use UniProt P62593 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P62593 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Beta-lactamase TEM as ChEMBL target CHEMBL2065, mapped to UniProt P62593. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Beta-lactamase TEM
SINGLE PROTEIN · Escherichia coli
As of 2026-09-13
ChEMBL target ID
CHEMBL2065
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P62593
Beta-lactamase TEM
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Beta-lactamase TEM is the right protein anchor across sources, using UniProt P62593 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBeta-lactamase TEM
Target TypeSINGLE PROTEIN
OrganismEscherichia coli
UniProtP62593
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-lactamase TEM
UniProt AccessionP62593
Component TypeProtein
Sequence Length286 aa

Beta-lactamase TEM

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Beta-lactamase TEM, mapped to UniProt P62593. Sequence length is 286 aa.

Mapped IDP62593
Review nameBeta-lactamase TEM
OrganismEscherichia coli
Clinical Profile

Clinical Phase Distribution

8
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50200.0
KI62.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL263746 9.4 IC50 0.4 Preclinical
CHEMBL212163 9.4 IC50 0.4 Preclinical
CHEMBL124416 9.0 IC50 1.0 Preclinical
CHEMBL122450 9.0 IC50 1.0 Preclinical
CHEMBL379856 9.0 IC50 1.0 Preclinical
CHEMBL380061 9.0 IC50 1.0 Preclinical
CHEMBL212760 9.0 IC50 1.0 Preclinical
CHEMBL378119 9.0 IC50 1.0 Preclinical
CHEMBL378041 8.7 IC50 2.0 Preclinical
CHEMBL385593 8.7 IC50 2.0 Preclinical
Distribution

pChEMBL Value Distribution

14
5.0
11
5.5
21
6.0
17
6.5
29
7.0
16
7.5
15
8.0
5
8.5
9
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TAZOBACTAM
CHEMBL404
Approved 1993
Properties Compare Identifier
TAZOBACTAM SODIUM
CHEMBL1439
Approved 1993
Properties Compare Identifier
SULBACTAM
CHEMBL403
Approved 1986
Properties Compare Identifier
CLAVULANIC ACID
CHEMBL777
Approved 1984
Properties Compare Identifier
Assay Landscape

Assay Landscape

85
Total Assays
157
Tested Compounds
2
Assay Types
Binding — 76 assays, 157 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 76 157 6.4
Functional — 9 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 9 5 6.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine