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Target Snapshot

CHEMBL2066 Target Snapshot

Troponin C, slow skeletal and cardiac muscles · SINGLE PROTEIN · Homo sapiens

7Compounds
6Assays
2Approved Drugs
18.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P63316. Use UniProt P63316 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P63316 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Troponin C, slow skeletal and cardiac muscles as ChEMBL target CHEMBL2066, mapped to UniProt P63316. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Troponin C, slow skeletal and cardiac muscles
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2066
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P63316
Troponin C, slow skeletal and cardiac muscles
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Troponin C, slow skeletal and cardiac muscles is the right protein anchor across sources, using UniProt P63316 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTroponin C, slow skeletal and cardiac muscles
UniProt AccessionP63316
Component TypeProtein
Sequence Length161 aa

Troponin C, slow skeletal and cardiac muscles

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Troponin C, slow skeletal and cardiac muscles, mapped to UniProt P63316. Sequence length is 161 aa.

Mapped IDP63316
Review nameTroponin C, slow skeletal and cardiac muscles
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC505.0
KD13.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL169107 5.82 Kd 1500.0 Preclinical
CHEMBL1191567 5.72 Kd 1900.0 Preclinical
CHEMBL485099 5.62 Kd 2400.0 Preclinical
CHEMBL5430893 5.48 Kd 3300.0 Preclinical
CHEMBL314854 5.3 Kd 5000.0 Approved
CHEMBL5429897 4.98 Kd 10400.0 Preclinical
CHEMBL1191567 4.66 IC50 21900.0 Preclinical
CHEMBL169107 4.58 IC50 26000.0 Preclinical
CHEMBL314854 4.54 IC50 29100.0 Approved
CHEMBL485099 4.37 IC50 42500.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
3
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

6
Total Assays
12
Tested Compounds
1
Assay Types
Binding — 6 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 4 7 5.1
single protein format 2 5 4.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine