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Target Snapshot

CHEMBL2069 Target Snapshot

Thromboxane A2 receptor · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
3,516Compounds
307Assays
8Approved Drugs
1,696.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Thromboxane A2 receptor shows approved-linked disease relevance led by Airway obstruction. 4 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P21731. Start with Airway obstruction, then reuse UniProt P21731 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with Airway obstruction, then reuse UniProt P21731 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
Airway obstruction

Thromboxane A2 receptor shows approved-linked disease relevance led by Airway obstruction. 4 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with Airway obstruction because it currently carries approved-linked support. Linked drugs include SERATRODAST. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Thromboxane A2 receptor as ChEMBL target CHEMBL2069, mapped to UniProt P21731. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Thromboxane A2 receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2069
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P21731
Thromboxane A2 receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Thromboxane A2 receptor is the right protein anchor across sources, using UniProt P21731 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why Airway obstruction is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameThromboxane A2 receptor
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP21731
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelThromboxane A2 receptor
UniProt AccessionP21731
Component TypeProtein
Sequence Length343 aa

Thromboxane A2 receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Thromboxane A2 receptor, mapped to UniProt P21731. Sequence length is 343 aa.

Mapped IDP21731
Review nameThromboxane A2 receptor
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Thromboxane A2 receptor shows approved-linked disease relevance led by Airway obstruction. 4 more disease programs remain visible in the same review block.

Approved-linked Approved
Airway obstruction
1 linked drug · 1 direct · 1 efficacy
Linked drugSERATRODAST
Approved-linked Approved
Recurrent thrombophlebitis
1 linked drug · 1 direct · 1 efficacy
Linked drugPICOTAMIDE
Clinical signal Phase II
asthma
1 linked drug · 1 direct · 1 efficacy
Linked drugRAMATROBAN
Clinical signal Phase II
COVID-19
1 linked drug · 1 direct · 1 efficacy
Linked drugRAMATROBAN
Clinical signal Phase II
pulmonary arterial hypertension
1 linked drug · 1 direct · 1 efficacy
Linked drugTERBOGREL
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with Airway obstruction because it currently carries approved-linked support. Linked drugs include SERATRODAST. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseAirway obstruction
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

8
Approved
1
Phase III
13
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50769.0
KI531.0
EC50141.0
KD255.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3354618 10.82 IC50 0.015 Preclinical
CHEMBL31146 10.3 Kd 0.05 Preclinical
CHEMBL3354616 10.28 IC50 0.052 Preclinical
CHEMBL31765 10.0 Kd 0.1 Preclinical
CHEMBL435382 9.89 IC50 0.13 Preclinical
CHEMBL30743 9.7 Kd 0.2 Preclinical
CHEMBL30615 9.7 Kd 0.2 Preclinical
CHEMBL3967284 9.52 EC50 0.3 Preclinical
CHEMBL281959 9.52 Kd 0.3 Preclinical
CHEMBL283923 9.52 Kd 0.3 Preclinical
Distribution

pChEMBL Value Distribution

142
5.0
208
5.5
178
6.0
160
6.5
168
7.0
145
7.5
106
8.0
58
8.5
32
9.0
7
9.5
pChEMBL
Approved Drugs

Approved Drugs

RAMATROBAN
CHEMBL361812
Approved 2000
Properties Compare Identifier
SERATRODAST
CHEMBL70972
Approved 1995
Properties Compare Identifier
LAROPIPRANT
CHEMBL426559
Properties Compare Identifier
Assay Landscape

Assay Landscape

307
Total Assays
597
Tested Compounds
3
Assay Types
Binding — 199 assays, 597 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 111 158 6.3
assay format 46 324 7.2
cell-based format 25 71 7.4
cell membrane format 13 43 7.2
tissue-based format 4 1 4.7
Functional — 107 assays, 513 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 49 191 6.3
cell-based format 36 126 6.2
tissue-based format 11 66 7.5
cell-free format 10 130 5.9
single protein format 1 0 —
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine