Kelch-like ECH-associated protein 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Kelch-like ECH-associated protein 1 shows approved-linked disease relevance led by multiple sclerosis. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q14145. Start with multiple sclerosis, then reuse UniProt Q14145 as the stable protein anchor across project notes and exports.
Start with multiple sclerosis, then reuse UniProt Q14145 as the stable protein anchor across project notes and exports.
Kelch-like ECH-associated protein 1 shows approved-linked disease relevance led by multiple sclerosis. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.
Start review with multiple sclerosis because it currently carries approved-linked support. Linked drugs include DIMETHYL FUMARATE, DIROXIMEL FUMARATE, MONOMETHYL FUMARATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyKelch-like ECH-associated protein 1
Review this target as Kelch-like ECH-associated protein 1, mapped to UniProt Q14145. Sequence length is 624 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Kelch-like ECH-associated protein 1 as ChEMBL target CHEMBL2069156, mapped to UniProt Q14145. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Kelch-like ECH-associated protein 1 is the right protein anchor across sources, using UniProt Q14145 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why multiple sclerosis is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Kelch-like ECH-associated protein 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q14145 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Kelch-like ECH-associated protein 1 |
| UniProt Accession | Q14145 |
| Component Type | Protein |
| Sequence Length | 624 aa |
Kelch-like ECH-associated protein 1
Review this target as Kelch-like ECH-associated protein 1, mapped to UniProt Q14145. Sequence length is 624 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Kelch-like ECH-associated protein 1 shows approved-linked disease relevance led by multiple sclerosis. 5 more disease programs remain visible in the same review block.
Start review with multiple sclerosis because it currently carries approved-linked support. Linked drugs include DIMETHYL FUMARATE, DIROXIMEL FUMARATE, MONOMETHYL FUMARATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4644995 | 10.15 | Kd | 0.07 | Preclinical |
| CHEMBL4643134 | 9.15 | Kd | 0.7 | Preclinical |
| CHEMBL4633657 | 9.06 | Kd | 0.88 | Preclinical |
| CHEMBL3819587 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL5567793 | 9.0 | Kd | 1.0 | Preclinical |
| CHEMBL3819587 | 8.89 | Kd | 1.3 | Preclinical |
| CHEMBL4634531 | 8.72 | Kd | 1.91 | Preclinical |
| CHEMBL4446699 | 8.7 | EC50 | 2.0 | Preclinical |
| CHEMBL4557371 | 8.7 | EC50 | 2.0 | Preclinical |
| CHEMBL4077198 | 8.68 | Ki | 2.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 92 | 135 | 6.2 |
| single protein format | 75 | 247 | 6.1 |
| assay format | 55 | 96 | 5.8 |
| biochemical format | 2 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| biochemical format | 1 | 0 | — |