Tyrosine-protein kinase Yes · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Tyrosine-protein kinase Yes shows clinical signal disease relevance led by cancer. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P07947. Start with cancer, then reuse UniProt P07947 as the stable protein anchor across project notes and exports.
Start with cancer, then reuse UniProt P07947 as the stable protein anchor across project notes and exports.
Tyrosine-protein kinase Yes shows clinical signal disease relevance led by cancer. 1 linked drug remains visible in the same block.
Start review with cancer because it currently carries clinical signal support. Linked drugs include JNJ-26483327. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyTyrosine-protein kinase Yes
Review this target as Tyrosine-protein kinase Yes, mapped to UniProt P07947. Sequence length is 543 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein kinase Yes as ChEMBL target CHEMBL2073, mapped to UniProt P07947. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Tyrosine-protein kinase Yes is the right protein anchor across sources, using UniProt P07947 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why cancer is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Tyrosine-protein kinase Yes |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P07947 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase Yes |
| UniProt Accession | P07947 |
| Component Type | Protein |
| Sequence Length | 543 aa |
Tyrosine-protein kinase Yes
Review this target as Tyrosine-protein kinase Yes, mapped to UniProt P07947. Sequence length is 543 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Tyrosine-protein kinase Yes shows clinical signal disease relevance led by cancer.
Start review with cancer because it currently carries clinical signal support. Linked drugs include JNJ-26483327. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL400402 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL5416410 | 9.52 | Kd | 0.3 | Approved |
| CHEMBL5280844 | 9.41 | IC50 | 0.39 | Preclinical |
| CHEMBL288441 | 9.4 | IC50 | 0.4 | Approved |
| CHEMBL5416410 | 9.3 | IC50 | 0.5 | Approved |
| CHEMBL217092 | 9.15 | IC50 | 0.7 | Clinical |
| CHEMBL3651257 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL3426225 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL3647967 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL1171837 | 9.05 | IC50 | 0.89 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 395 | 181 | 7.2 |
| cell-based format | 42 | 19 | 5.3 |
| assay format | 40 | 6 | 7.6 |
| subcellular format | 13 | 35 | 6.5 |
| cell membrane format | 1 | 1 | 8.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |