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Target Snapshot

CHEMBL2073673 Target Snapshot

Solute carrier family 22 member 3 · SINGLE PROTEIN · Homo sapiens

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91Compounds
32Assays
18Approved Drugs
48.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-12

Protein identity stays anchored to UniProt O75751. Use UniProt O75751 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O75751 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-12
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Solute carrier family 22 member 3 as ChEMBL target CHEMBL2073673, mapped to UniProt O75751. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Solute carrier family 22 member 3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-12
ChEMBL target ID
CHEMBL2073673
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-12
www.ebi.ac.uk
UniProt accession
O75751
Solute carrier family 22 member 3
UniProt accession via ChEMBL component mapping As of 2026-09-12
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-12
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Solute carrier family 22 member 3 is the right protein anchor across sources, using UniProt O75751 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSolute carrier family 22 member 3
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtO75751
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSolute carrier family 22 member 3
UniProt AccessionO75751
Component TypeProtein
Sequence Length556 aa

Solute carrier family 22 member 3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Solute carrier family 22 member 3, mapped to UniProt O75751. Sequence length is 556 aa.

Mapped IDO75751
Review nameSolute carrier family 22 member 3
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

18
Approved
1
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC5037.0
KI10.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL339858 7.82 Ki 15.0 Preclinical
CHEMBL2074900 7.3 IC50 50.0 Preclinical
CHEMBL1197556 7.05 IC50 90.0 Preclinical
CHEMBL107 6.92 Ki 120.0 Approved
CHEMBL110739 6.54 IC50 290.0 Clinical
CHEMBL4129927 6.4 IC50 400.0 Preclinical
CHEMBL790 6.39 IC50 410.0 Approved
CHEMBL255863 6.3 IC50 500.0 Approved
CHEMBL4100146 5.82 IC50 1500.0 Preclinical
CHEMBL2074851 5.75 IC50 1760.0 Preclinical
Distribution

pChEMBL Value Distribution

9
5.0
6
5.5
3
6.0
2
6.5
2
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

NILOTINIB
CHEMBL255863
Approved 2007
Properties Compare Identifier
CHLORHEXIDINE
CHEMBL790
Approved 1976
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
Assay Landscape

Assay Landscape

32
Total Assays
23
Tested Compounds
3
Assay Types
Binding — 16 assays, 20 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 19 5.0
single protein format 1 1 —
Functional — 11 assays, 23 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 23 5.7
ADME — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine