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Evidence Snapshot

Bile salt export pump

CHEMBL2073674 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:01:14Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2073674
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Bile salt export pump as ChEMBL target CHEMBL2073674, mapped to UniProt O70127. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Bile salt export pump
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL2073674
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O70127
Bile salt export pump
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Bile salt export pump matters

As of 2026-09-13

Bile salt export pump is reviewed as Bile salt export pump (UniProt O70127); the current evidence base includes 27 approved drugs, 107 compounds, and 32 assays, with lead potency reaching pChEMBL 6.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 27 approved drugs, 107 compounds, and 32 assays for this target. The dominant activity type is IC50. CHEMBL160 is the current potency anchor at pChEMBL 6.5.

Use CHEMBL160 as the tractability anchor when discussing potency (pChEMBL 6.5).

Activity source · ChEMBL 36 via Core Engine
27 approved pChEMBL 6.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Bile salt export pump matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt O70127, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

107
Total Compounds
32
Total Assays
27
Approved Drugs
IC50: 94.0, KI: 8.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL160
 6.5 Ki Approved
No preferred name
CHEMBL2074778
 6.4 IC50 —
No preferred name
CHEMBL160
 6.2 IC50 Approved
No preferred name
CHEMBL2074644
 5.9 IC50 —
No preferred name
CHEMBL595
 5.7 IC50 Approved

Approved Drugs

Structure Compound First Approval
CYCLOSPORINE
CHEMBL160
 1983
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:01:14Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2073674