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Target Snapshot

CHEMBL2081 Target Snapshot

Glutathione S-transferase Mu 1 · SINGLE PROTEIN · Homo sapiens

47Compounds
13Assays
0Approved Drugs
33.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P09488. Use UniProt P09488 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P09488 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glutathione S-transferase Mu 1 as ChEMBL target CHEMBL2081, mapped to UniProt P09488. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glutathione S-transferase Mu 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2081
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P09488
Glutathione S-transferase Mu 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glutathione S-transferase Mu 1 is the right protein anchor across sources, using UniProt P09488 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlutathione S-transferase Mu 1
UniProt AccessionP09488
Component TypeProtein
Sequence Length218 aa

Glutathione S-transferase Mu 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Glutathione S-transferase Mu 1, mapped to UniProt P09488. Sequence length is 218 aa.

Mapped IDP09488
Review nameGlutathione S-transferase Mu 1
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5024.0
KI9.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL58135 5.7 Ki 2000.0 Preclinical
CHEMBL301229 5.68 Ki 2100.0 Preclinical
CHEMBL1938641 5.5 Ki 3200.0 Preclinical
CHEMBL60581 4.96 Ki 11000.0 Preclinical
CHEMBL1938641 4.87 IC50 13400.0 Preclinical
CHEMBL442360 4.82 Ki 15100.0 Preclinical
CHEMBL58451 4.66 Ki 22000.0 Preclinical
CHEMBL1938640 4.47 IC50 33600.0 Preclinical
CHEMBL58507 4.39 Ki 41000.0 Preclinical
CHEMBL1938638 4.35 IC50 44500.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
3
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

13
Total Assays
15
Tested Compounds
2
Assay Types
Binding — 12 assays, 15 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 9 15 4.8
cell-based format 3 0
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine