Dopamine receptor · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P25115. Use UniProt P25115 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P25115 as the stable identity anchor, then attach disease evidence before program review.
D(1B) dopamine receptor
Review this target as Dopamine receptor, mapped to UniProt P25115. ChEMBL maps the protein component as D(1B) dopamine receptor. Sequence length is 475 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dopamine receptor as ChEMBL target CHEMBL2093868, mapped to UniProt P25115. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dopamine receptor |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | P25115 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | D(1B) dopamine receptor |
| UniProt Accession | P25115 |
| Component Type | Protein |
| Sequence Length | 475 aa |
D(1B) dopamine receptor
Review this target as Dopamine receptor, mapped to UniProt P25115. ChEMBL maps the protein component as D(1B) dopamine receptor. Sequence length is 475 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1788212 | 10.47 | Ki | 0.034 | Preclinical |
| CHEMBL1255588 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL544618 | 9.64 | Ki | 0.23 | Preclinical |
| CHEMBL54 | 9.55 | IC50 | 0.28 | Approved |
| CHEMBL38428 | 9.49 | IC50 | 0.32 | Preclinical |
| CHEMBL1204189 | 9.48 | Kd | 0.3337 | Preclinical |
| CHEMBL1423 | 9.4 | IC50 | 0.4 | Approved |
| CHEMBL295712 | 9.21 | IC50 | 0.61 | Preclinical |
| CHEMBL8946 | 9.04 | IC50 | 0.92 | Clinical |
| CHEMBL53 | 9.0 | IC50 | 1.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 25 | 97 | 6.8 |
| tissue-based format | 24 | 87 | 7.1 |
| protein format | 21 | 94 | 6.8 |
| assay format | 18 | 114 | 7.0 |
| organism-based format | 15 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 48 | 7 | 5.4 |
| tissue-based format | 19 | 10 | 7.7 |
| assay format | 13 | 19 | 7.7 |
| cell membrane format | 2 | 7 | 7.3 |