GABA-A receptor; anion channel · PROTEIN COMPLEX GROUP · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt P10063. Use UniProt P10063 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P10063 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid receptor subunit alpha-2
Review this target as GABA-A receptor; anion channel, mapped to UniProt P10063. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit alpha-2. Sequence length is 451 aa.
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This review treats GABA-A receptor; anion channel as ChEMBL target CHEMBL2094107, mapped to UniProt P10063. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | GABA-A receptor; anion channel |
| Target Type | PROTEIN COMPLEX GROUP |
| Organism | Bos taurus |
| UniProt | P10063 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit alpha-2 |
| UniProt Accession | P10063 |
| Component Type | Protein |
| Sequence Length | 451 aa |
Gamma-aminobutyric acid receptor subunit alpha-2
Review this target as GABA-A receptor; anion channel, mapped to UniProt P10063. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit alpha-2. Sequence length is 451 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL407 | 10.05 | Ki | 0.09 | Approved |
| CHEMBL407 | 9.3 | IC50 | 0.5 | Approved |
| CHEMBL452 | 9.07 | Ki | 0.85 | Approved |
| CHEMBL11908 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL11709 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL316824 | 8.74 | Kd | 1.8 | Preclinical |
| CHEMBL317545 | 8.74 | Kd | 1.8 | Preclinical |
| CHEMBL317815 | 8.74 | Kd | 1.8 | Preclinical |
| CHEMBL319058 | 8.74 | Kd | 1.8 | Preclinical |
| CHEMBL327853 | 8.74 | Kd | 1.8 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 27 | 149 | 6.6 |
| protein complex format | 22 | 14 | 5.9 |
| assay format | 13 | 72 | 6.8 |
| tissue-based format | 8 | 73 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |
| tissue-based format | 1 | 18 | 8.7 |