Neuronal acetylcholine receptor · PROTEIN COMPLEX GROUP · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P04757. Use UniProt P04757 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P04757 as the stable identity anchor, then attach disease evidence before program review.
Neuronal acetylcholine receptor subunit alpha-3
Review this target as Neuronal acetylcholine receptor, mapped to UniProt P04757. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit alpha-3. Sequence length is 499 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuronal acetylcholine receptor as ChEMBL target CHEMBL2094110, mapped to UniProt P04757. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Neuronal acetylcholine receptor |
| Target Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
| UniProt | P04757 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuronal acetylcholine receptor subunit alpha-3 |
| UniProt Accession | P04757 |
| Component Type | Protein |
| Sequence Length | 499 aa |
Neuronal acetylcholine receptor subunit alpha-3
Review this target as Neuronal acetylcholine receptor, mapped to UniProt P04757. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit alpha-3. Sequence length is 499 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3 | 11.0 | Kd | 0.01 | Approved |
| CHEMBL99886 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL6623 | 10.68 | Ki | 0.021 | Preclinical |
| CHEMBL430497 | 10.4 | Ki | 0.04 | Clinical |
| CHEMBL6623 | 10.39 | IC50 | 0.041 | Preclinical |
| CHEMBL262769 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL59986 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL97605 | 10.21 | Ki | 0.061 | Preclinical |
| CHEMBL419932 | 10.12 | Ki | 0.076 | Preclinical |
| CHEMBL333162 | 10.11 | Ki | 0.077 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 29 | 179 | 6.7 |
| protein complex format | 23 | 28 | 6.5 |
| assay format | 17 | 96 | 7.4 |
| cell membrane format | 11 | 76 | 7.9 |
| cell-based format | 2 | 8 | 5.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 2 | 5.5 |
| organism-based format | 3 | 0 | — |