MAP kinase p38 · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O15264. Use UniProt O15264 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O15264 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase 13
Review this target as MAP kinase p38, mapped to UniProt O15264. ChEMBL maps the protein component as Mitogen-activated protein kinase 13. Sequence length is 365 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats MAP kinase p38 as ChEMBL target CHEMBL2094115, mapped to UniProt O15264. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | MAP kinase p38 |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | O15264 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase 13 |
| UniProt Accession | O15264 |
| Component Type | Protein |
| Sequence Length | 365 aa |
Mitogen-activated protein kinase 13
Review this target as MAP kinase p38, mapped to UniProt O15264. ChEMBL maps the protein component as Mitogen-activated protein kinase 13. Sequence length is 365 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL194813 | 10.33 | Ki | 0.047 | Preclinical |
| CHEMBL363643 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL196741 | 10.24 | Ki | 0.057 | Preclinical |
| CHEMBL197206 | 10.24 | Ki | 0.057 | Preclinical |
| CHEMBL103667 | 10.01 | Kd | 0.097 | Clinical |
| CHEMBL318810 | 10.0 | Kd | 0.1 | Preclinical |
| CHEMBL305178 | 9.96 | IC50 | 0.11 | Preclinical |
| CHEMBL195532 | 9.82 | Ki | 0.15 | Preclinical |
| CHEMBL545353 | 9.82 | IC50 | 0.15 | Preclinical |
| CHEMBL197351 | 9.8 | Ki | 0.16 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 198 | 27 | 7.0 |
| protein format | 125 | 319 | 6.9 |
| assay format | 38 | 94 | 6.9 |
| tissue-based format | 4 | 4 | 8.5 |
| mitochondrion format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 23 | 152 | 7.0 |
| cell-based format | 17 | 115 | 6.4 |
| tissue-based format | 13 | 52 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 1 | 6 | 6.9 |