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Target Snapshot

CHEMBL2094123 Target Snapshot

Serotonin (5-HT) receptor · PROTEIN FAMILY · Rattus norvegicus

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195Compounds
36Assays
13Approved Drugs
134.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P35563. Use UniProt P35563 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P35563 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serotonin (5-HT) receptor as ChEMBL target CHEMBL2094123, mapped to UniProt P35563. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serotonin (5-HT) receptor
PROTEIN FAMILY · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL2094123
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P35563
5-hydroxytryptamine receptor 3A
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serotonin (5-HT) receptor is the right protein anchor across sources, using UniProt P35563 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameSerotonin (5-HT) receptor
Target TypePROTEIN FAMILY
OrganismRattus norvegicus
UniProtP35563
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label5-hydroxytryptamine receptor 3A
UniProt AccessionP35563
Component TypeProtein
Sequence Length483 aa

5-hydroxytryptamine receptor 3A

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Serotonin (5-HT) receptor, mapped to UniProt P35563. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 3A. Sequence length is 483 aa.

Mapped IDP35563
Review nameSerotonin (5-HT) receptor
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

13
Approved
1
Phase III
6
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5030.0
KI2.0
KD102.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL415 8.3 IC50 5.0 Approved
CHEMBL516 8.1 Kd 7.943 Approved
CHEMBL134519 7.63 Kd 23.44 Preclinical
CHEMBL38992 7.58 IC50 26.0 Clinical
CHEMBL1788278 7.49 Kd 32.36 Preclinical
CHEMBL6616 7.49 Kd 32.36 Preclinical
CHEMBL11 7.36 IC50 44.0 Approved
CHEMBL629 7.36 IC50 44.0 Approved
CHEMBL6607 7.35 Kd 44.67 Clinical
CHEMBL267526 7.2 Kd 63.1 Preclinical
Distribution

pChEMBL Value Distribution

32
5.0
29
5.5
17
6.0
21
6.5
15
7.0
3
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CLOMIPRAMINE
CHEMBL415
Approved 1989
Properties Compare Identifier
PERGOLIDE
CHEMBL531
Approved 1988
Properties Compare Identifier
DOXEPIN
CHEMBL1628227
Approved 1969
Properties Compare Identifier
NORTRIPTYLINE
CHEMBL445
Approved 1964
Properties Compare Identifier
DESIPRAMINE
CHEMBL72
Approved 1964
Properties Compare Identifier
CYPROHEPTADINE
CHEMBL516
Approved 1961
Properties Compare Identifier
AMITRIPTYLINE
CHEMBL629
Approved 1961
Properties Compare Identifier
IMIPRAMINE
CHEMBL11
Approved 1959
Properties Compare Identifier
Assay Landscape

Assay Landscape

36
Total Assays
106
Tested Compounds
2
Assay Types
Binding — 23 assays, 106 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 11 52 6.3
assay format 6 48 5.8
tissue-based format 6 6 6.3
Functional — 13 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 8 1 5.1
assay format 5 1 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine