Cyclin-dependent kinase 2/cyclin E · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P24864. Use UniProt P24864 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P24864 as the stable identity anchor, then attach disease evidence before program review.
G1/S-specific cyclin-E1
Review this target as Cyclin-dependent kinase 2/cyclin E, mapped to UniProt P24864. ChEMBL maps the protein component as G1/S-specific cyclin-E1. Sequence length is 410 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cyclin-dependent kinase 2/cyclin E as ChEMBL target CHEMBL2094126, mapped to UniProt P24864. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cyclin-dependent kinase 2/cyclin E is the right protein anchor across sources, using UniProt P24864 as the stable mapping.
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| Preferred Name | Cyclin-dependent kinase 2/cyclin E |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P24864 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | G1/S-specific cyclin-E1 |
| UniProt Accession | P24864 |
| Component Type | Protein |
| Sequence Length | 410 aa |
G1/S-specific cyclin-E1
Review this target as Cyclin-dependent kinase 2/cyclin E, mapped to UniProt P24864. ChEMBL maps the protein component as G1/S-specific cyclin-E1. Sequence length is 410 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2103840 | 9.0 | Ki | 1.0 | Clinical |
| CHEMBL328406 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4446357 | 9.0 | Ki | 1.0 | Clinical |
| CHEMBL5286090 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL126997 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL298445 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL355631 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL420463 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL430653 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL575888 | 8.7 | IC50 | 2.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 117 | 660 | 6.6 |
| cell-based format | 6 | 32 | 6.0 |
| assay format | 1 | 1 | 7.3 |