Cyclin-dependent kinase 1/cyclin B · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P06493. Use UniProt P06493 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P06493 as the stable identity anchor, then attach disease evidence before program review.
Cyclin-dependent kinase 1
Review this target as Cyclin-dependent kinase 1/cyclin B, mapped to UniProt P06493. ChEMBL maps the protein component as Cyclin-dependent kinase 1. Sequence length is 297 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cyclin-dependent kinase 1/cyclin B as ChEMBL target CHEMBL2094127, mapped to UniProt P06493. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cyclin-dependent kinase 1/cyclin B |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P06493 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cyclin-dependent kinase 1 |
| UniProt Accession | P06493 |
| Component Type | Protein |
| Sequence Length | 297 aa |
Cyclin-dependent kinase 1
Review this target as Cyclin-dependent kinase 1/cyclin B, mapped to UniProt P06493. ChEMBL maps the protein component as Cyclin-dependent kinase 1. Sequence length is 297 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL261720 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL384350 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL426509 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL212552 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL377449 | 8.72 | IC50 | 1.9 | Preclinical |
| CHEMBL212299 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL361900 | 8.68 | IC50 | 2.1 | Preclinical |
| CHEMBL388978 | 8.62 | IC50 | 2.4 | Preclinical |
| CHEMBL2103840 | 8.52 | Ki | 3.0 | Clinical |
| CHEMBL212491 | 8.52 | IC50 | 3.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 129 | 417 | 6.2 |
| cell-based format | 17 | 135 | 5.9 |
| assay format | 1 | 19 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 17 | 4.3 |